抗VEGF治疗湿性老年性黄斑变性的效果及对其视力的影响

Effectiveness of Anti-VEGF Treatment for Wet Age-related Macular De⁃generation and Its Effect on Their Visual Acuity

目的探讨湿性老年性黄斑变性患者采取抗VEGF方案治疗的临床效果及对改善视力的影响。方法方便选取2020年9月-2022年6月常州市第七人民医院眼科收诊治疗的118例湿性老年性黄斑病变患者,根据就诊时间先后顺序分为对照组(2020年9月-2021年6月,59例)与观察组(2021年7月-2022年6月,59例),对照组患者采用视网膜光凝/光动力疗法治疗,观察组患者实施抗VEGF(阿柏西普玻璃体注射)治疗,比较两组患者治疗后视网膜的血管及血液循环状态,两组患者治疗后脉络膜新生血管(CNV)渗漏情况;检测两组患者治疗前后不同时间视力及黄斑中心凹视网膜厚度变化。结果观察组患者治疗后视网膜的血管及血液循环状态总有效率为96.61%,高于对照组,差异有统计学意义(χ^(2)=9.241,P<0.05)。观察组患者治疗后CNV渗漏情况改善总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者治疗前裸眼视力、黄斑中心凹视网膜厚度测定结果比较,差异无统计学意义(P>0.05),观察组患者治疗后1、3个月裸眼视力高于对照组,视网膜厚度低于对照组,差异有统计学意义(P<0.05)。结论湿性老年性黄斑变性患者通过抗VEGF方案治疗具有良好疗效,可促进患者视力恢复,减小视网膜厚度。

Objective To investigate the clinical effect of anti-VEGF regimen in patients with wet age-related macular degeneration and its impact on improving visual acuity.Methods 118 patients with wet age-related macular disease admitted to the ophthalmology department of Changzhou Seventh People's Hospital from September 2020 to June 2022 were conveniently selected and divided into control group(59 patients from September 2020 to June 2021)and observation group(59 patients from July 2021 to June 2022)according to the order of time of treatment.The control group patients were treated with retinal photocoagulation/photodynamic therapy,and the observation group patients were treated with anti-VEGF(intravitreal injection of alboxepril).The retinal blood vessels and blood circulation of the two groups of patients after treatment;the leakage of choroidal neovascularization(CNV)of the two groups of patients after treatment were compared;the changes of visual acuity and macular fovea retinal thickness of the two groups of patients at different times before and after treatment were detected.Results The total effective rate of retinal blood vessels and blood circulation in the observation group after treatment was 96.61%higher than that in the control group,the difference was statistically significant(χ^(2)=9.241,P<0.05).The total effective rate of improvement of CNV leakage in the observation group after treatment was higher than that in the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference between the two groups in the results of naked eye vision and macular fovea retinal thickness measurement before treatment(P>0.05).The naked eye vision of the patients in the observation group was higher than that in the control group at 1 and 3 months after treatment,and the retinal thickness was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion The treatment of wet age-related macular degeneration patients with anti-VEGF regimen has good efficacy,can promote the recovery of visual acuity and reduce retinal thickness,and advocate the use of promotion.