同步放化疗与序贯化放疗在中晚期食管癌患者中的应用分析

Analysis of Synchronous Radiotherapy and Sequential Radiotherapy in Patients with Intermediate and Advanced Esophageal Cancer

目的 探讨中晚期食管癌(esophageal cancer, ES)患者行同步放化疗与序贯化放疗治疗取得的效果。方法方便选取2020年1月-2022年3月龙岩市第二医院收治的68例中晚期ES患者作为研究对象,按照随机数表将其分为研究组(34例)与对照组(34例)。研究组行同步放化疗治疗,对照组行序贯化放疗治疗。针对两组临床疗效、治疗前后血清肿瘤标志物,以及不良反应发生情况进行观察与比较。结果 研究组总有效率85.29%较对照组58.82%高,差异有统计学意义(χ^(2)=5.916,P<0.05)。治疗前两组CYFRA21-1与SCC水平比较,差异无统计学意义(P>0.05);治疗后研究组CYFRA21-1与SCC水平较对照组低,差异有统计学意义(P<0.05)。研究组放射性气管炎发生率为14.71%、放射性食管炎为8.82%、骨髓抑制为14.71%、恶心呕吐为23.53%、转氨酶升高为2.94%与对照组为17.65%、14.71%、17.65%、29.41%、8.82%比较,差异无统计学意义(χ^(2)=0.109、0.142、0.109、0.302、0.266,P>0.05)。结论 相较于序贯化放疗,同步放化疗治疗中晚期ES的效果更为显著,具有临床推广及应用价值。

Objective To investigate the effect of synchronous radiotherapy and sequential radiotherapy in patients with intermediate and advanced esophageal cancer(ES).Methods 68 patients with intermediate and advanced ES admitted to Longyan Second Hospital were conveniently selected as study subjects from January 2020 to March 2022.They were divided into a study group(thirty-four cases)and a control group(thirty-four cases)according to the random number table.The study group was treated with synchronous radiotherapy,and the control group was treated with sequential radiotherapy.The clinical efficacy,serum tumor markers before and occurrence of after treatment,and adverse reactions of the two groups were observed and compared.Results The total effective rate of the research group was 85.29%was higher than 58.82%in the control group,the difference was statistically significant(χ^(2)=5.916,P<0.05).There was no statistically significant difference in the results of the two groups in the comparison of CYFRA21-1 and SCC levels before treatment(P>0.05).After treatment,The levels of CYFRA21-1 and SCC in the study group were lower than those in the control group,the difference was statistically significant(P<0.05).The incidence of radiation tracheitis 14.71%,radiation esophagitis 8.82%,bone marrow suppression 14.71%,nausea and vomiting 23.53%,and transaminase elevation 2.94%in the study group and 17.65%,14.71%,17.65%,29.41%,and 8.82%in the control group were compared,the difference was not statistically significant(χ^(2)=0.109,0.142.0.109,0.302,0.266,P>0.05).Conclusion Compared with sequential radiotherapy,the effect of synchronous radiotherapy for the treatment of intermediate and advanced ES is more significant and has clinical promotion and application value.