柴胡加龙骨牡蛎汤联合西药治疗抑郁症的效果分析

Analysis of the Effectiveness of Combining Bupleurum Plus Longgu Oyster Decoction with Western Medicine in the Treatment of Major Depressive Disorder

目的 探讨柴胡加龙骨牡蛎汤联合西药治疗抑郁症(major depressive disorde,MDD)的效果。方法 方便选取2020年1月—2021年12月在福建省福能集团总医院接受治疗的121例MDD患者,以随机数表法将其分为研究组(60例)与对照组(61例)。对照组采用常规西药治疗,研究组在此基础上应用柴胡加龙骨牡蛎汤治疗。针对两组临床疗效、睡眠障碍情况、生活质量与不良反应情况进行比较。结果 研究组总有效率为96.67%较对照组的83.61%高,差异有统计学意义(χ^(2)=5.775,P<0.05)。治疗8周时,研究组匹兹堡睡眠指数量表(PSQI)评分较对照组低,差异有统计学意义(P<0.05),生存质量测定量表(QOL-BREF)量表中生理、心理、社会、环境评分较对照组高,差异有统计学意义(P<0.05)。研究组不良反应发生率为5.00%与对照组的1.64%比较,差异无统计学意义(χ^(2)=0.276,P>0.05)。结论 柴胡加龙骨牡蛎汤联合西药治疗MDD效果确切,安全性较佳,能够有效改善患者的抑郁症状,保障其睡眠质量与生活质量,具有临床推广价值。

Objective To investigate the effect of bupleurum plus Longgu oyster decoction combined with western medicine in the treatment of major depressive disorder(MDD).Methods A total of 121 MDD patients who were treated at Fujian Funeng Group General Hospital from January 2020 to December 2021 were conveniently selected and divided into a study group(60 cases)and a control group(61 cases)with a random number table method.The control group was treated with conventional western medicine,and the research group was treated with Chaihu plus Longgu Oyster soup on this basis.The clinical efficacy,sleep disorders,quality of life,and adverse reactions were compared between the two groups.Results The total effective rate in the study group was 96.67%higher than 83.61%in the control group,the difference was statistically significant(χ^(2)=5.775,P<0.05).After 8 weeks of treatment,the Pittsburgh sleep quality index(PSQI)score was lower than that in the control group,the difference was statistically significant(P<0.05);the physiological,psychological,social,the environmental score of the control group was higher than those in the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was 5.00%compared to 1.64%in the control group,the difference was not statistically significant(χ^(2)=0.276,P>0.05).Conclusion Bupleurum plus Longgu oyster decoction combined with western medicine for MDD has exact effect and better safety,which can effectively improve patients'depressive symptoms and guarantee their sleep quality and quality of life,and has clinical promotion value.