氨溴索辅助治疗肺部感染的有效性及对肺功能、炎性介质指标的影响

Efficacy of Ambroxol in Adjuvant Treatment of Pulmonary Infection and Its Effect on Lung Function and Inflammatory Mediators

目的 分析肺部感染患者采取氨溴索辅助治疗的效果。方法 方便选取2019年6月—2021年7月福州经济技术开发区医院收治的88例肺部感染患者为研究对象,双盲法随机分为两组,各44例。对照组进行常规治疗,观察组在此基础上采用氨溴索辅助治疗。比较两组疗效、肺功能与炎性介质水平。结果 观察组与对照组总有效率比较(90.91%vs 72.73%),差异有统计学意义(χ^(2)=4.889,P=0.027);观察组C反应蛋白(CRP)、降钙素原(PCT)与血清淀粉样蛋白A(SAA)水平分别为(10.35±2.11)mg/L、(1.06±0.31)ng/L、(9.62±3.22)mg/L,均低于对照组的(13.26±2.42)mg/L、(1.32±0.42)ng/L、(12.65±3.52)mg/L,差异有统计学意义(t=6.012、3.304、4.213,P<0.05);观察组各项肺功能指标高于对照组,差异有统计学意义(P<0.05)。结论 给予肺部感染患者氨溴索辅助治疗可有效改善患者肺功能,促使炎症反应减轻,提高治疗效果。

Objective To analyze the effect of ambroxol adjuvant treatment in patients with pulmonary infection.Methods 88 patients with pulmonary infection admitted to Fuzhou Economic and Technological Development Zone Hospital from June 2019 to July 2021 were conveniently selected as the research objects,and double-blind method was randomly divided into two groups with 44 patients each.The control group received conventional treatment,and the observation group received ambroxol adjuvant treatment on this basis.The efficacy,lung function and inflammatory mediators were compared between the two groups.Results Compared the total effective rate of observation group and control group(90.91%vs 72.73%),and the difference was statistically significant(χ^(2)=4.889,P=0.027).The levels of C-reactive protein(CRP),procalcitonin(PCT)and serum amyloid A(SAA)in the observation group were(10.35±2.11)mg/L,(1.06±0.31)ng/L and(9.62±3.22)mg/L,respectively,were lower than the control group(13.26±2.42)mg/L,(1.32±0.42)ng/L and(12.65±3.52)mg/L,and the difference was statistically significant(t=6.012,3.304,4.213,P<0.05).The lung function indexes of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Adjuvant treatment with ambroxol in patients with pulmonary infection can effectively improve lung function,reduce inflammatory response and improve therapeutic effect.