超早期小骨窗微创脑出血清除术对高血压脑出血患者临床疗效及炎性因子水平的影响

Effect of Ultra-early Small Bone Window Minimally Invasive Cerebral Hemorrhage Removal on Clinical Efficacy and Inflammatory Factor Levels in Patients with Hypertensive Cerebral Hemorrhage

目的 探讨高血压脑出血患者给予超早期小骨窗微创脑出血清除术对临床疗效及炎性因子水平的影响。方法 回顾性选取2016年1月—2021年8月平度市人民医院收治的106例高血压脑出血患者为研究对象,按照随机摸球法分成观察组(53例)与对照组(53例)。对照组给予常规大骨瓣开颅术,观察组给予超早期小骨窗微创脑出血清除术。比较两组临床疗效、临床指标、炎性因子及并发症发生率。结果 观察组治疗总有效率(90.57%)明显较对照组(73.58%)更高,差异有统计学意义(χ^(2)=5.194,P<0.05)。与对照组比较,观察组手术时间、住院时间明显更短,术中出血量明显更少,血肿清除率明显更高,差异有统计学意义(P<0.05)。两组术后超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平均有明显降低,且观察组较对照组明显更低,差异有统计学意义(P<0.05)。观察组并发症发生率(5.66%)较对照组(24.53%)明显更低,差异有统计学意义(P<0.05)。结论 超早期小骨窗微创脑出血清除术用于高血压脑出血患者的治疗效果较好,可改善临床指标,调节炎性因子水平,减少并发症的发生。

Objective To investigate the effects of minimally invasive cerebral hemorrhage removal with ultra-early small bone windows on clinical efficacy and inflammatory factor levels in patients with hypertensive cerebral hemorrhage given.Methods One hundred and six patients with hypertensive cerebral hemorrhage admitted to Pingdu People′s Hospital from January 2016 to August 2021 were retrospectively selected as the study objects and divided into observation group(53 cases) and control group(53 cases) according to the randomized ball touching method.The control group was given conventional large bone flap craniotomy,and the observation group was given ultra-early small bone window minimally invasive cerebral hemorrhage removal.The clinical efficacy,clinical indexes,inflammatory factors and complication rates of the two groups were compared.Results The total effective rate of treatment in the observation group(90.57%) was significantly higher than that in the control group(73.58%),and the difference was statistically significant(χ^(2)=5.194,P<0.05).Compared with the control group,the observation group had significantly shorter operative time and hospital stay,significantly less intraoperative bleeding,and significantly higher hematoma clearance rate,and the difference was statistically significant(P<0.05).The levels of hypersensitive Creactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6) were significantly lower in both groups after surgery,and the observation group were significantly lower than the control group,and the difference was statistically significant(P<0.05).The complication rate in the observation group(5.66%) was significantly lower than that in the control group(24.53%),and the difference was statistically significant(P<0.05).Conclusion Minimally invasive cerebral hemorrhage removal with an ultra-early small bone window is more effective in the treatment of patients with hypertensive cerebral hemorrhage,improving clinical indicators,regulating inflammatory factor levels,and reducing the occurrence of complications.