生长抑素结合丹参注射液对重症急性胰腺炎患者炎性因子与急慢性健康评分的影响

Effects of Somatostatin Combined with Salvia Miltiorrhiza Injection on Inflammatory Factor and Acute and Chronic Health Scores in Patients with Severe Acute Pancreatitis

目的 探究生长抑素结合丹参注射液对重症急性胰腺炎(severe acute pancreatitis,SAP)患者炎性因子与急慢性健康评分的影响。方法 于2019年1月—2020年10月随机选择厦门大学附属第一医院收治的60例SAP患者作为研究对象,按照随机数表法进行分组,对照组(n=30)给予生长抑素治疗,观察组(n=30)结合丹参注射液治疗。对比分析两组治疗效果。结果 治疗后,观察组总有效率达到96.67%,高于对照组,差异有统计学意义(χ^(2)=4.706,P=0.030)。观察组血清钙(2.31±0.22)nmol/L高于对照组,APACHEⅡ评分(7.95±2.02)分、血清淀粉酶(209.95±52.32)U/L以及炎性因子水平CRP、MCP-1、NLR(9.95±2.32)mg/L、(18.95±3.72)pg/mL、(5.45±1.32)低于对照组,差异有统计学意义(t=4.934、3.750、4.830、3.248、4.246、4.443,P<0.05)。治疗后,两组不良反应发生率对比,差异无统计学意义(χ^(2)=1.298,P>0.05)。结论 对SAP患者采用联合治疗有利于提高疗效,稳定患者体内血清炎性因子,调节血清钙、血清淀粉酶水平,降低患者急慢性性健康评分。

Objective To explore the effect of somatostatin combined with salvia miltiorrhiza injection on inflammatory factor and acute and chronic health scores in patients with severe acute pancreatitis(SAP).Methods From January 2019 to October 2020,60 patients with SAP admitted to the First Affiliated Hospital of Xiamen University were randomly selected as the study subjects and divided into groups according to the random number table method.The control group(n=30)was treated with somatostatin,and the observation group(n=30)combined with salvia miltiorrhiza injection.Compared and analyzed the treatment effect of the two groups.Results After treatment,the effective rate of the observation group reached 96.67%,which was higher than that of the control group,the difference was statistically significant(χ^(2)=4.706,P=0.030).The serum calcium(2.31±0.22)nmol/L in the observation was higher than that of the control group,the APACHEⅡscore(7.95±2.02)points,the serum amylase(209.95±52.32)U/L,and the levels of inflammatory factors CRP,MCP-1,and NLR were(9.95±2.32)mg/L,(18.95±3.72)pg/mL,(5.45±1.32),which were lower than that of the control group,the difference was statistically significant(t=4.934,3.750,4.830,3.248,4.246,4.443,P<0.05).After treatment,there was no statistically significant difference in the incidence of adverse reactions between the two groups(χ^(2)=1.298,P>0.05).Conclusion Combined treatment for SAP patients is beneficial to improve the curative effect,stabilize the serum inflammatory factors,regulate the levels of serum calcium and serum amylase,and reduce the patients´acute and chronic sexual health scores.