糖尿病肾病患者C反应蛋白与高密度脂蛋白胆固醇比值对急性肾损伤发生的预测价值

Prediction Value of C-reactive Protein to High-density Lipoprotein Cholesterol Ratio for Acute Renal Injury in Patients with Diabetes Nephropathy

目的研究C反应蛋白(CRP)与高密度脂蛋白胆固醇(HDL-C)比值对糖尿病肾病患者急性肾损伤发生的预测价值。方法选取驻马店市第四人民医院于2019年4月至2021年5月收治的糖尿病肾病患者为研究对象,共纳入68例。所有患者入院后通过临床资料调查表统计年龄、既往饮酒史、体重指数(BMI)等资料;通过酶联免疫吸附法、自动生化仪等方法测量CRP、HDL-C、肌酐、糖化血红蛋白等实验室指标,并计算CRP/HDL-C的数值。于治疗期间,统计68例患者急性肾损伤发生情况,将其分为发生组和未发生组;绘制受试者工作特征(ROC)曲线,分析CRP、HDL-C、CRP/HDL-C对糖尿病肾病患者急性肾损伤发生的预测价值。结果治疗期间,68例糖尿病肾病患者中发生急性肾损伤21例,占比为30.88%;发生组CRP、肌酐、CRP/HDL-C高于未发生组(P<0.05);两组患者临床资料和其他实验室指标对比,差异无统计学意义(P>0.05);点二列相关结果显示,CRP、肌酐、CRP/HDL-C与糖尿病肾病患者急性肾损伤发生呈正相关(r>0,P<0.05);绘制ROC曲线,CRP、肌酐、CRP/HDL-C预测糖尿病肾病患者急性肾损伤发生的曲线下面积(AUC)分别为0.708、0.757、0.905,具有一定的预测效能。结论肌酐、CRP、CRP/HDL-C与糖尿病肾病患者急性肾损伤发生有关,其中CRP/HDL-C对糖尿病肾病患者急性肾损伤发生有预测价值,其值越高,急性肾损伤发生可能性越大。

Objective To study the predictive value of C-reactive protein(CRP)to high-density lipoprotein cholesterol(HDL-C)ratio for acute renal injury in patients with diabetes nephropathy.Methods A total of 68 patients with diabetes nephropathy who were admitted to the Fourth People’s Hospital of Zhumadian from April 2019 to May 2021 were selected as the study subjects.After admission,the data such as age,previous drinking history and body mass index(BMI)were collected by clinical data questionnaire.The laboratory indexes such as CRP,HDL-C,creatinine and glycosylated hemoglobin were measured by enzyme-linked immunosorbent assay and automatic biochemical analyzer,and the CRP/HDL-C values were calculated.During the treatment,the incidence of acute renal injury in 68 patients was counted,and they were divided into the occurrence group and the non-occurrence group according to the occurrence of acute renal injury.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of CRP,HDL-C and CRP/HDL-C in the occurrence of acute renal injury in patients with diabetes nephropathy.Results During the treatment,acute renal injury occurred in 21 of 68 patients with diabetes nephropathy,accounting for 30.88%.CRP,creatinine and CRP/HDL-C in the occurrence group were higher than those in the non-occurrence group(P<0.05).There was no statistical difference between the clinical data of the two groups and other laboratory indicators(P>0.05).The binary correlation results showed that CRP,creatinine,CRP/HDL-C were positively correlated with the occurrence of acute renal injury in patients with diabetes nephropathy(r>0,P<0.05).ROC curve was drawn,and the area under the curve(AUC)of CRP,creatinine and CRP/HDL-C to predict the occurrence of acute renal injury in patients with diabetes nephropathy were 0.708,0.757 and 0.905,respectively,which had certain predictive efficacy.Conclusion Creatinine,CRP,CRP/HDL-C are related to the occurrence of acute renal injury in patients with diabetes nephropathy.CRP/HDL-C have predictive value for the occurrence of acute renal injury in patients with diabetes nephropathy,and the higher their values,the greater the possibility of acute renal injury.