摘要
长链非编码RNA(lncRNA)是一类长度大于200个核苷酸的RNA转录本。配对盒基因8反义RNA1(PAX8-AS1)是lncRNA的一种,在甲状腺癌、乳腺癌、子宫内膜癌、急性白血病、肾上腺皮质癌等多种恶性肿瘤中异常表达,通过作为竞争性内源RNA和其单核苷酸多态性等机制调节癌细胞的增殖、凋亡、侵袭和耐药性,对癌症的诊断、治疗及预后具有非常重要的价值。本文就lncRNA PAX8-AS1在恶性肿瘤中的作用机制及潜在应用进行综述。
Long non-coding RNA(lncRNA)is a kind of RNA transcript with a length of more than 200 nucleotides.Paired box gene 8 antisense strand 1(PAX8-AS1)is a kind of lncRNA,which is abnormally expressed in many malignant tumors such as thyroid cancer,breast cancer,endometrial cancer,acute leukemia and adrenal cortical cancer.It can regulate the proliferation,apoptosis,invasion and drug resistance of cancer cells through the mechanism of being competitive endogenous RNA and single nucleotide polymorphism of PAX8-AS1,which are of great value to the diagnosis,treatment and prognosis of cancer.In this paper,the mechanism and potential application of lncRNA PAX8-AS1 in malignant tumors are viewed.
作者
任子瑞
徐登飞
仓顺东
REN Zirui;XU Dengfei;CANG Shundong(Cancer Center,Henan University People’s Hospital/Henan Provincial People’s Hospital,Zhengzhou 450003,China)
出处
《河南医学研究》
CAS
2023年第7期1340-1344,共5页
Henan Medical Research
基金
河南省自然科学基金(222300420570)
河南省科技研发专项(212102310161)
河南省医学科技攻关计划联合共建项目(LHGJ20220051)。