内皮功能、炎症、神经系统退行性疾病的生物标志物与小动脉硬化型CSVD的关联

Association of biomarkers of endothelial function,inflammation,and neurodegenerative diseases with arteriosclerotic cerebral small vessel disease

脑小血管病(CSVD)是导致老年人痴呆的主要原因,目前研究发现部分内皮功能、炎症、神经系统退变疾病的生物标志物与小动脉硬化型CSVD存在关联,可能对CSVD的发病有提示意义。本综述对这些生物标志物进行总结,以期理解CSVD的发病机制,为其早期诊断和治疗提供思路。

Cerebral small vessel disease(CSVD)is a major cause of dementia in elderly.Some studies showed that biomarkers of endothelial dysfunction,inflammation and neurodegenerative diseases are associated with arteriosclerotic CSVD,which may indicated the development of CSVD.The review summaries these biomarkers to provide an insight into the pathogenesis,early diagnosis and treatment in CSVD.