维生素E对放疗或化疗导致的口腔黏膜炎有效性的meta分析

Effectiveness of vitamin E on oral mucositis caused by radiotherapy and chemotherapy:a meta-analysis

目的·评价维生素E在治疗放射治疗或化学治疗(放化疗)导致的口腔黏膜炎(oral mucositis,OM)中的有效性。方法·计算机检索PubMed、Embase、Cochrane Library、Web of Science、CINAHL、OpenGrey、中国生物医学文献数据库、中国知网、万方数据库和维普中文期刊数据库中关于维生素E用于放化疗后的OM有效性的随机对照研究,检索时限为建库至2022年3月。由2位研究者独立按照纳入和排除标准筛选文献、提取资料和评价纳入文献的方法学质量后,采用RevMan 5.4软件进行meta分析。结果·共检索出563篇文献,最终纳入7项随机对照试验。Meta分析结果显示:使用维生素E治疗放化疗导致的OM的效果,相较于对照组,差异无统计学意义(RR=0.44,95%CI 0.15~1.25,Z=1.54,P=0.120);维生素E对于重度OM可能有一定的效果(RR=0.22,95%CI 0.11~0.43,Z=4.33,P=0.000),差异具有统计学意义。结论·暂不能说明使用维生素E能够有效治疗放化疗导致的OM,但维生素E对于重度OM可能有效。

Objective·To examine,using a systematic review and meta-analysis,the effectiveness of vitamin E on treating oral mucositis caused by radiotherapy and chemotherapy.Methods·A systematic literature search was performed by using PubMed,Embase,Cochrane Library,Web of Science,CINAHL,OpenGrey,Chinese biomedical literature database(CBM),Chinese national knowledge infrastructure(CNKI),Wanfang Data,and China Science and Technology Journal Database(VIP).The retrieval time was up to March 2022.The risk of bias was assessed by using the Cochrane Risk-of-Bias tool,version 2.0.RevMan 5.4 was used for meta-analysis.Results·A total of 563 literatures were retrieved.A total of 7 randomized controlled trials were included.The results of meta-analysis revealed that vitamin E supplementation did not significantly affect oral mucositis caused by chemoradiotherapy(RR=0.44,95%CI 0.15?1.25,Z=1.54,P=0.120).However,vitamin E may have some effect on severe oral mucositis(RR=0.22,95%CI 0.11?0.43,Z=4.33,P=0.000).Conclusion·It cannot be explained that vitamin E can effectively treat oral mucositis caused by radiotherapy and chemotherapy,but vitamin E may be effective for severe oral mucositis.