氟比洛芬酯超前镇痛对无痛人工流产术中丙泊酚用量及麻醉效果的影响

Effcts of preemptive analgesia with flurbiprofen axetil on the dosage and the anesthetic effect of propofol during painless induced abortion

目的:探讨氟比洛芬酯进行超前镇痛对无痛人工流产术中丙泊酚用量及麻醉效果的影响。方法:选取2021年1月-2022年7月在本院行无痛人工流产手术90例,根据入院时间的不同随机分为对照组(n=40)和观察组(n=50)。两组麻醉方式相同,对照组和观察组麻醉诱导前分别静注氯化钠注射液与氟比洛芬酯。对比两组围术期血流动力学指标、麻醉效果、丙泊酚用量及不良反应等。结果:术前,两组的收缩压(SBP)、舒张压(DBP)、心率(HR)、血氧饱和度(SpO_(2))水平无差异(P>0.05);术中,两组SBP、DBP、HR、SpO_(2)水平均较术前降低(P<0.05),观察组HR水平高于对照组(P<0.05);术后,两组清醒时SBP、DBP、HR、SpO_(2)水平与术前未见差异(P>0.05)。两组麻醉诱导时间无差异(P>0.05)。观察组手术时间(4.33±0.37 min)、麻醉苏醒时间(4.62±1.52 min)、丙泊酚用量(2.50±0.32 mg/kg)、总不良反应发生率(22.0%)低于对照组(5.12±0.29 min、6.91±2.32 min、3.31±0.42 mg/kg、42.5%),麻醉总有效率(94.0%)高于对照组(77.5%)(P<0.05)。结论:在无痛人工流产术中应用氟比洛芬酯进行超前镇痛能够有效提高麻醉效果,减少丙泊酚用量,减少麻醉药物相关不良反应的发生,缩短手术时间及麻醉苏醒时间。

Objective:To investigate the effects of preemptive analgesia with flurbiprofen axetil on the dosage and the anesthetic effect of propofol during painless induced abortion.Methods:90 women who wanted painless abortion were selected and were randomly divided into two groups according to their different admission time from J anuary 2021 to July 2022.The women in the two groups were given same anesthetized way during painless induced abortion,40 women in the control group were given sodium chloride injection intravenously before anesthesia induction,and 50 women in the study group were given flurbiprofen axetil injection intravenously before anesthesia induction.The perio-perative hemodynamic indexes,the anesthetic effect,the propofol dosage,and the adverse reactions rate of the women were compared between the two groups.Results:There were no significant differences in the values of systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR),and oxygen saturation(SpO_(2))of the women be-fore surgery between the two groups(P>20.05).The values of SBP,DBP,HR,and SpO_(2) of the women in the two groups during abortion were significantly lower than those before abortion(P<0.05).The HR value of the women in the study group was significantly higher than that of the women in the control group(P<0.05).The SBP,DBP,HR,and SpO_(2) values of the women in the two groups when awaking after abortion had no significant different from those before abortion(P>0.05).The operation time(4.33±0.37 min),the recovery time after anesthesia(4.62±1.52 min),the propofol dosage(2.50±0.32 mg/kg),and the total incidence of adverse reactions(22.0%)of the women in the study group were significantly lower than those(5.12±0.29 min,6.91±2.32 min,3.31±0.42 mg/kg,and 42.5%)of the women in the control group,but the total effective rate of anesthesia(94.0%)of the women in the study group was significantly higher than that(77.5%)of the women in the control group(P<0.05).Conclusion:The application of flurbiprofen axetil for preemptive analgesia of the women during the painless abortion can effectively improve their anesthetic effect,reduce the dosage of propofol,reduce their occurrence of anesthetic related adverse re-actions,and shorten their abortion time and anesthesia recovery time.