子痫前期患者抗磷脂抗体水平及与凝血纤溶指标关系

Correlation between the antiphospholipid antibody level of pregnant w omen with preeclampsia and the values of their C0af ulation and fibrinolysis indexes

目的:分析子痫前期(PE)患者抗磷脂抗体(APA)水平及与血栓形成性疾病指标的关系。方法:纳入2019年8月-2022年3月本院收治的75例PE患者,产前检查健康孕妇50例,收集两组血液标本,采用酶联免疫吸附法检测血清APA-IgG、APA-IgM、抗β2-GPI抗体水平,使用血凝仪检测D-二聚体、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、抗凝血酶Ⅲ、血小板聚集试验(PAgT)水平;比较两组APA、抗β2-GPI抗体水平、凝血纤溶指标;采用Spearman相关法分析抗体与凝血纤溶指标相关性。结果:PE组APA-IgG、APA-IgM、抗β2-GPI抗体水平高于健康组(均P<0.05),APTT水平两组无差异(P>0.05),D-二聚体、FIB、PAgT水平均高于健康组,PT、抗凝血酶Ⅲ水平均低于健康组(均P<0.05);PE组中APA-IgG、APA-IgM、抗β2-GPI抗体阳性与阴性患者PT水平无差异(P>0.05),D-二聚体、FIB、PAgT水平阳性患者高于阴性患者,抗凝血酶Ⅲ水平阳性患者低于阴性患者(均P<0.05)。Spearman相关性分析,APA-IgG、APA-IgM、抗β2-GPI抗体与D-二聚体、FIB、PAgT水平呈正相关,与抗凝血酶Ⅲ呈负相关(均P<0.05)。结论:PE患者APA-IgG、APA-IgM、抗β2-GPI抗体水平上升,且与凝血纤溶指标相关。

Objective:To analyze the correlation between the antiphospholipid antibody(APA)level of pregnant women with preeclampsia(PE)and the values of their thrombotic diseases indexes.Methods:75 pregnant women with PE were selected in study group and another 50 healthy pregnant women were selected in control group from August 2019 to March 2022.The blood samples of the women in the two groups were olleted.The levels of serum APA-IgG,APA-IgM,and anti-P2-GPI of the women in the two groups were detected by enzyme-linked immunosorbent assay..The D-dimer level,and the values of activated partial thromboplastin time(APTT),prothrombin time(PT),fibrino-gen(FIB)。antithrombin 1,and platelet aggregation test(PAgT)of the women in the two groups were detected by blood coagulation analyzer.The APA and anti-2-GPI antibodies levels and the coagulation and fibrinolysis indexes val-ues of the women were compared between the two groups.Spearman correlation method was used to analyze the corte lation between the antibody level of the women and their coagulation and fibrinolysis indexes values.Resuts:The lev-els of APA-IgG,APA-IgM.and anti-2 Gpi antibodies of the women in the study group were signifiantly higher than those of the women in the control group(all P<0.05).but there was no significant dflerence in the APTT level of the women between two groups(P>0.05).The levels of D-dimer,FIB,and PAgT of the women in the study group were significantly higher than those of the women in the control group.The levels of PT and antithrombin M of the women in the study group were significantly lower than those of the women in the control group(all P<0.05).In the study group.there was no significant dflerence in the PT level between the women with positive APA-IgG,APA-IgM.and anti-i2-GPI and the women with negative APA-IgG,APA-IgM.and anti-2-GPI(P>0.05).The levels of D-dimer,FIB,and PAgT of the women with positive APA-IgG,APA-IgM,and anti-92-GPI were significantly higher than those of the women with negative APA-IgG.APA-IgM,and anti-92-GPI.but which of the women with positive positive an-tithrombin were significantly lower than those of the women with negative antithrombin I(all P<0.05).Spearman correlation analysis slhowed that the levels of APA-IgG,APA-IgM,and antipP-GPI antibodies of the women were positively correlated with the levels of their D-dimer,FIB,and PAgT,and which were negatively correlated with the antithrombin I level of the women(all P<0.05).Conclusiom:The levels of APA-IgG,APA-IgM.and anti-p2-GPI antibodies of the pregnant women with PE increase,and which are related to the coagulation and fibrinolysis inde xes of the women.