子宫肌瘤患者超声弹性成像参数及血清miR-34a、sFlt-1表达及诊断价值

Values of ultrasonographic elastic imaging parameters and the expression levels of serum microRNA-34a and sFLt-1 of women with uterine fibroids and their diagnostic values for uterine fibroids

目的:探究经腹部超声弹性成像参数子宫动脉搏动指数(PI)、阻力指数(RI)、弹性应变力比值(SR)及血清miR-34a、sFlt-1在子宫肌瘤患者中的表达及诊断价值。方法:选取2021年4月-2022年4月本院收治的子宫肌瘤患者50例为子宫肌瘤组,正常体检健康女性50例为对照组,分析两组超声参数、miR-34a、sFLt-1、SR水平;观察miR-34a、sFLt-1与临床特征及与子宫肌瘤发病关系;探究经腹部超声弹性成像参数、miR-34a、sFLt-1对子宫肌瘤的诊断价值。结果:子宫肌瘤组PI、RI、miR-34a低于对照组,sFLt-1及SR高于对照组,且子宫肌瘤组中有阴道不规则出血患者血清miR-34a、sFLt-1表达异常更高(均P<0.05);miR-34a与子宫肌瘤发病率呈负相关,sFLt-1与子宫肌瘤发病率呈正相关;腹部超声弹性成像参数、血清miR-34a及sFLt-1均对子宫肌瘤有一定诊断价值,但各指标联合检测价值更高,曲线下面积0.901,诊断敏感度91.4%、特异性94.1%。结论:子宫肌瘤患者PI、RI、SR、miR-34a、sFLt-1均异常,miR-34a、sFLt-1与子宫肌瘤发病具相关性;腹部超声弹性成像参数联合血清miR-34a、sFLt-1检测对子宫肌瘤有较高诊断价值。

Objective:To investigate the values of ultrasonographic elastic imaging parameters of uterine artery,such as pulsation index(PD),resistance index(RI),elastic stress ratio(SR),and the expression levels of serum microRNA-34a(miR-34a)and sFLt-1(soluble vascular endothelial growth factor receptor-1)of women with uterine fibroids,and to study their diagnostic values for uterine fibroids.Methods:50 women with uterine fibroids were selected in study group,and 50 healthy women who accepted physical examination were selected in control group from April 2021 to A-pril 2022.The values of PI,RI,and SR,and the expression levels of miR-34a and sFLt-1 of the women in the two groups were analyzed.The correlation between the miR-34a and sFLt1 levels of the women with uterine fibroids and their clinical features and their uterine fibroids occurrence was observed.The diagnostic values of transabdominal ultra-sonographic elastic imaging parameters and the levels of serum miR-34a and sFlt-1 of the women for their uterine fi-broids were explored.Results:The values of PI and RI,and the miR 34a level of the women in the study group were significantly lower than those of the women in the control group,but the sFLt1 level and the SR value of the women in the study group were significantly higher.The levels of miR-34a and sFLt-1 of the women with irregular vaginal bleeding in the study group were significantly higher than those women without irregular vaginal bleeding(all P<0.05).The miR-34a level of the women was negatively correlated with the occurrence of their uterine fibroids,while the sFLt1 level was positively correlated with the occurrence of their uterine fibroids.The elastic imaging parameters by abdominal ultrasound,and the serum miR-34a and sFLt-1 levels of the women all had a certain diagnostic value for their uterine fibroids.The value of the combined the elastic imaging parameters and the serum miR 34a and sFLt1 lev-els for diagnosing uterine fibroids was significantly higher than the elastic imaging parameters or the serum miR-34a and sFLt1 levels alone,and the area under the curve,the sensitivity,and the specificity of which were 0.901,91.4%,and 94.1%,respectively.Conclusion:The values of PI,RI,and SR,and the miR-34a and sFLt-1 levels of the women with uterine fibroids are all abnormally,and the miR-34a and sFLt-1 levels of the women are correlation with their oc-currence of uterine fibroids.The value of the combination of the elastic imaging parameters and the serum miR-34a and sFLt-1 levels for diagnosing uterine fibroids is higher.