炎症免疫反应在解痉多肽表达化生恶性转化中的研究进展

Research progress on inflammatory immune response in malignant transformation of spasmolytic polypeptide expressing metaplasia

胃癌是全球发病率和病死率排名前五的癌症之一,其发生发展遵循Correa’s演进模式,而肠上皮化生(IM)是该演进过程中的癌前状态。近年来研究人员发现了另一化生状态,即解痉多肽表达化生(SPEM),SPEM在动物模型中的可逆性提示“该化生状态可能是胃黏膜萎缩发生后较IM更为早期的事件”,并且与胃癌密切相关。其中,炎症免疫相关细胞因子在SPEM向胃癌的转变中发挥着极为重要的作用。该文就具体炎症通路和相关因子在SPEM发生发展中的作用研究做一综述。

Gastric cancer is one of the top five cancers in global morbidity and mortality,and its occurrence and development follows the Correa’s evolution model,while the intestinal metaplasia(IM)is a pre-cancerous state in this process.In recent years,another metaplastic state,spasmolytic polypeptide expression metaplasia(SPEM),has been discovered.The reversibility of SPEM in animal models suggests that this metaplastic state may be an earlier event after gastric mucosal atrophy than IM,and is closely correlated with gastric cancer.Among them,the inflammatory immune-related cytokines play an extremely important role in the transformation of SPEM into gastric cancer.This paper reviews the role of specific inflammatory pathways and factors in the occurrence and development of SPEM.