铝碳酸镁联合奥美拉唑对骨折患者术后应激性溃疡的作用价值

Effect and value of Aluminum Magnesium Carbonate combined with Omeprazole on postoperative stress ulcer in fracture patients

目的探讨铝碳酸镁联合奥美拉唑对骨折患者术后应激性溃疡(SU)的作用价值。方法选取2021年7月至2022年6月于抚州市第二人民医院骨科治疗的60例骨折术后SU患者作为研究对象,采用随机数字表法将其分为对照组(30例)及观察组(30例)。对照组患者采用奥美拉唑治疗,观察组患者于对照组基础上采用铝碳酸镁治疗。比较两组患者的治疗效果、血清胃泌素-17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、视觉模拟评分法(VAS)评分、世界卫生组织生活质量问卷调查表(WHOQOL-BREF)评分及不良反应发生情况。结果观察组患者的治疗总有效率(93.33%)高于对照组(73.33%),差异有统计学意义(P<0.05);治疗后,观察组患者的G-17、PGⅠ、PGⅡ水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组患者的VAS评分低于对照组,WHOQOL-BREF评分高于对照组,差异有统计学意义(P<0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论骨折术后SU患者采用铝碳酸镁与奥美拉唑联合治疗,有利于降低患者的G-17、PGⅠ及PGⅡ水平,改善胃肠道功能及生活质量,缓解疼痛程度,临床应用安全性高。

Objective To investigate the effect and value of Aluminum Magnesium Carbonate combined with Omeprazole on postoperative stress ulcer(SU)in fracture patients.Methods From July 2021 to June 2022,60 postoperative SU in fracture patients who were treated in the Department of Orthopedics of Fuzhou Second People's Hospital were selected as the research objects.They were divided into the control group(30 cases)and the observation group(30 cases)by random number table method.The control group was treated with Omeprazole.Observation group was treated with Aluminum Magnesium Carbonate on the basis of control group.The therapeutic effect,serum gastrin-17(G-17),pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),visual analogue scale(VAS),WHO quality of life questionnaire(WHOQOL-BREF)and adverse reactions were compared between the two groups.Results The total effective rate of the observation group(93.33%)was higher than that of the control group(73.33%),the difference was statistically significant(P<0.05).After treatment,the levels of G-17,PGⅠand PGⅡin the observation group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the VAS score of observation group was lower than that of the control group,and the WHOQOL-BREF score of observation group was higher than that of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined treatment of Aluminum Magnesium Carbonate and Omeprazole for SU patients after fracture surgery is beneficial to reduce the levels of G-17,PGⅠand PGⅡ,improve gastrointestinal function and quality of life,relieve pain to a certain extent,and has high clinical safety.