急性心肌梗死患者PCI治疗后支架内再狭窄发生的影响因素

Influencing factors of in-stent restenosis after PCI in patients with acute myocardial infarction

目的探讨急性心肌梗死(AMI)患者经皮冠状动脉介入(PCI)治疗后支架内再狭窄(ISR)发生的影响因素。方法抽取2019年1月至2021年1月信阳市中心医院收治的AMI患者170例,按照ISR发生情况将其分为发生组和未发生组。由研究人员询问患者基线资料并记录研究所需资料,将可能的影响因素纳入Logistic回归分析,分析AMI患者PCI治疗后ISR发生的影响因素。结果170例AMI患者PCI治疗后经1年随访,发生ISR 28例(16.47%),未发生ISR 142例(83.53%)。发生组基础疾病、血清同型半胱氨酸(HCY)水平、血清白细胞介素18(IL-18)水平以及负面情绪与未发生组比较,差异有统计学意义(P<0.05),两组其余基线资料比较,差异未见统计学意义(P>0.05)。Logistic回归分析结果显示,合并基础疾病、HCY过表达、血清IL-18过表达、有负面情绪是AMI患者PCI治疗后ISR发生的影响因素(OR>1,P<0.05)。结论AMI患者PCI治疗后发生ISR可能与合并基础疾病、血清HCY过表达、血清IL-18过表达、有负面情绪等因素有关。

Objective To investigate the influencing factors of in-stent restenosis(ISR)after percutaneous coronary intervention(PCI)in patients with acute myocardial infarction(AMI).Methods A total of 170 AMI patients admitted to Xinyang Central Hospital from January 2019 to January 2021 were selected,and the patients were divided into the occurrence group and the non-occurrence group according to the occurrence of ISR.The researchers inquired about the baseline data of the patients,and recorded the data required for the study.The possible influencing factors were enrolled into the Logistic regression analysis,and the influencing factors of ISR in AMI patients after PCI were analyzed.Results After 1-year follow-up of 170 patients with AMI after PCI,28 cases(16.47%)developed ISR,and 142 cases(83.53%)did not have ISR.There were statistically significant differences in the underlying diseases,level of serum homocysteine(HCY),level of serum interleukin-18(IL-18),and negative emotions between the occurrence group and the non-occurrence group(P<0.05),however,there was no significant difference in the rest of the baseline data between the two groups(P>0.05).The results of Logistic regression analysis showed that underlying diseases,overexpression of serum HCY,overexpression of serum IL-18,and negative emotions were the influencing factors of ISR in AMI patients after PCI(OR>1,P<0.05).Conclusions The occurrence of ISR in AMI patients after PCI treatment may be related to underlying diseases,serum HCY overexpression,serum IL-18 overexpression,and negative emotions.