幼年期小鼠双酚F暴露对其行为的影响

Effects of juvenile bisphenol F exposure on the behavior of mice

双酚F(bisphenol F,BPF)作为双酚A(bisphenol A,BPA)的主要替代物,对大脑功能影响的研究并不多。文章以幼年期(21~49 d)为时间窗口,通过不同的行为学范式研究BPF暴露对小鼠行为的影响。研究发现,1 mg/(kg·d)BPF暴露不会影响小鼠的体质量、饮水量等生理状态,但显著减少小鼠进入旷场中央区的时间与次数,增加小鼠在悬尾、强迫游泳时的静止时间以及减弱小鼠在三箱社交中与陌生鼠1的交流,而与陌生鼠2的交流时间没有变化。结果表明,幼年期小鼠BPF暴露会诱导其焦虑与抑郁样行为,损害小鼠的社交能力。该研究将为BPF引起的神经系统损伤提供有价值的信息,并在工业生产中为BPA替代物的选择提供理论依据。

There are few researches on the effects of bisphenol F(BPF),the main substitute of bisphenol A(BPA),on brain function.This paper chose the juvenile(21-49 d)as exposure time window to study the effects of BPF on the behavior of mice through different behavioral paradigms.The results showed that 1 mg/(kg·d)BPF treatment did not affect the physiological status of mice,such as body weight and water consumption,but significantly reduced the time and frequency of mice entering the central area in open field test,increased the immobile time of mice in tail suspension test and forced swimming test and weakened the sniffing time with strange mice 1 while the social novelty with strange mice 2 had no changes in three-chamber test.Those results suggested that juvenile BPF exposure could induce anxiety-and depressive-like behaviors and impair the social ability of mice.This paper will provide valuable information for BPF-induced nervous system impairments and provide theoretical basis for industrial production choosing BPA alternative as raw material.