乳糜泻与幽门螺杆菌感染相关性的Meta分析

The relationship between Celiac disease and Helicobacter pylori infection:a Meta-analysis

目的探讨乳糜泻与幽门螺杆菌(Helicobacter pylori,H.pylori)感染的相关性。方法收集已发表的乳糜泻患者感染H.pylori的文献,记录发表年份、地区、第一作者、研究人群及检测方法等,建立Meta回归模型并同时进行亚组分析及异质性检测。结果共检索316篇文献,最终8篇符合入选标准。入选文献共纳入2635例患者,H.pylori总感染率为36.02%。Meta分析结果显示,乳糜泻患者与健康对照组比较,H.pylori感染率差异无统计学意义,乳糜泻与H.pylori感染呈负相关。亚组分析提示,南美洲人群中乳糜泻患者的H.pylori感染率高于对照组,乳糜泻与H.pylori呈正相关,而欧洲、亚洲人群中乳糜泻患者的H.pylori感染率低于对照组;2010年及之后的乳糜泻患者中H.pylori感染率低于对照组,2010年之前的乳糜泻患者中H.pylori感染率与对照组比较差异无统计学意义(P>0.05);采用H+RUT检测H.pylori感染时乳糜泻组H.pylori感染率低于对照组,差异有统计学意义(P<0.05),采用H与RUT,H+ELISA、ELISA检测方法时乳糜泻患者中H.pylori感染率与对照组比较差异无统计学意义(P>0.05)。结论乳糜泻患者与健康人群H.pylori感染率无差异,但2010年前后发表的研究与采用不同H.pylori的检测方法对乳糜泻患者H.pylori的感染率存在影响。

Objective To explore the relationship between Celiac disease and Helicobacter pylori(H.pylori)infection.Methods The published literature on the incidence of H.pylori infection in Celiac disease patients was collected,and the published year,region,first author,research population and detection methods were recorded.Meta regression model was established and subgroup analysis and heterogeneity test were performed at the same time.Results A total of 316 articles were searched,8 of which met the selection criteria.A total of 2635 patients were included in the selected literature,and the total H.pylori infection rate was 36.02%.Meta analysis showed that there was a significant difference in H.pylori infection rate between Celiac disease patients and healthy controls,and there was a negative correlation betwee Celiac disease and H.pylori infection.Subgroup analysis showed that the infection rate of H.pylori in patients with Celiac disease in South America was higher than that in the control group,and there was a positive correlation between Celiac disease and H.pylori,while the infection rate of H.pylori in patients with Celiac disease in Europe and Asia was lower than that in the control group.The H.pylori infection rate in Celiac disease patients after 2010 was lower than that in the control group.Before 2010,there was no significant difference in H.pylori infection rate between Celiac disease patients and the control group.The H.pylori infection rate in the Celiac disease group was lower than that in the control group,when H+RUT was used for detecting H.pylori infection,and the difference was statistically significant,H and RUT were adopted.H.pylori infection rates in Celiac disease patients did not differ significantly from controls on the H+ELISA,ELISA test.Conclusion There is no difference in H.pylori infection rate between Celiac disease patients and healthy people.The literature about Celiac disease patients before and after 2010,different H.pylori detection methods have influence on H.pylori infection rate in Celiac disease patients.