益生菌代谢产物对病原菌的抑菌作用研究进展

Research progress in the antibacterial effect of probiotic metabolites on pathogens

益生菌能产生多种具有抑菌活性的代谢产物,且均具有广谱的抑菌效果,能够满足人们对抗菌药物绿色、健康的要求,有望成为一种环境友好型的微生物源抑菌剂。益生菌所产代谢产物种类繁多,主要有有机酸、细菌素、过氧化氢等,其抑菌机理多样,不仅能够破坏病原菌细胞壁膜结构,影响膜电位;还能在胞内破坏生物大分子,干扰菌体代谢,或影响DNA、RNA生物活性;也可以竞争病原菌中生长相关物质结合位点,阻止细胞生长分裂。该文有望对益生菌代谢产物作为新型抑菌活性物质的广泛应用提供理论依据。

Probiotics are able to produce a variety of metabolites with broad-spectrum antibacterial activity.They can satisfy the people′s requirements for greenness and health and are expected to be environment-friendly antimicrobial agents.The metabolites include organic acid,bacteriocin,hydrogen peroxide,etc.They can take antimicrobial actions in different mechanisms.They are able to destroy the structure of cell envelope and affect the membrane potential.They can destroy the biological macromolecules,interfere with cell metabolism,or affect the biological activities of DNA and RNA.Besides,they can also compete for the binding sites of the growth-related substances in pathogens to inhibit cell growth and division.The result is expected to provide a theoretical basis for the wide application of probiotic metabolites as new antimicrobial substances.