不同哮喘程度与炎性因子水平及肺功能相关性研究

Correlation Study of Different Degree of Asthma and Levels of Inflammatory Factor and Lung Function

目的:探讨哮喘患儿白细胞介素6(interleukin 6,IL-6)、嗜酸性粒细胞(eosinophil, E)、中性粒细胞(neutrophil, N)、超敏C反应蛋白(high-sensitivity C-reactive protein, hs-CRP)水平及肺功能结果与其哮喘症状严重程度的关系。方法:2021年8月至2022年8月于随州市中心医院就诊的113例哮喘患儿(观察组),根据症状严重程度分为轻、中、重3组。选取同期27名健康体检儿童作为对照组,比较观察组与对照组和观察组轻、中、重不同程度患儿IL-6、E%、N%、hs-CRP水平及肺功能结果。结果:观察组患儿IL-6、hs-CRP、E%、N%、支气管舒张试验后最大呼气峰流速(BDT FEV1)改善率明显高于对照组,而第1秒用力呼气容积(FEV1)、最大呼气峰流速(PEF)、第1秒用力呼气容积与用力肺活量比值(FEV1/FVC)、用力呼气中期流速(MEF75/25)明显低于对照组,差异有统计学意义(P<0.05)。观察组轻、中、重三组患儿比较,IL-6、E%、N%、hs-CRP水平重度组明显较轻、中度组高(P<0.05),轻、中度组间差异无统计学意义(P>0.05);而FEV1、FEV1/FVC、PEF、MEF75/25重度组低于轻、中度组,BDT FEV1改善率重度组高于轻、中度组,三组间差异均有统计学意义(P<0.05)。结论:IL-6、E%、N%、hs-CRP水平及肺功能结果在不同严重程度哮喘患儿间差异较为明显,可以对哮喘的严重程度进行大致的评估。

Objective To investigate the relationship between the levels of interleukin 6(IL-6),eosinophil%(E%),neu⁃trophil%(N%),hypersensitive C-reactive protein(hs-CRP)and the severity of asthma symptoms in children with asth⁃ma.Methods From August 2021 to August 2022,113 children with asthma(observation group)who visited Suizhou Cen⁃tral Hospital were divided into mild,moderate and severe groups according to the severity of symptoms.A total of 27 healthy children in the same period were selected as the control group,and the IL-6,E%,N%,hs-CRP levels and pulmonary function results were compared between the observation group and the control group and the observation group with mild,moderate and severe children.Results The improvement rate of IL-6,hs-CRP,E%,N%,and BDT FEV1 after bron⁃chodilator test in the observation group was significantly higher than that in the control group,while FEV1,PEF,FEV1/FVC,MEF75/25 were significantly lower than those in the control group(P<0.05).Compared with the mild,moderate,and severe groups of children in the observation group,the levels of IL-6,E%,N%,and hs-CRP in the severe group were significantly higher than those in the mild and moderate groups(P<0.05),but there was no statistically significant difference between mild and moderate groups(P>005).However,the FEV1,FEV1/FVC,PEF,and MEF75/25 in se⁃vere group were lower than those in the mild and moderate groups,and the improvement rate of BDT FEV1 in the severe group was higher than that in the mild and moderate groups.The differences among the three groups were statistically signif⁃icant(P<0.05).Conclusion IL-6,E%,N%,hs-CRP levels and pulmonary function are significantly different among children with different severity of asthma,which can roughly evaluate the severity of asthma.