中性粒细胞与淋巴细胞比值、细胞角蛋白19片段及人附睾蛋白4检测在子宫内膜癌诊断中的应用

Application of NLR,CYFRA21-1 and HE4 detection in the diagnosis of endometrial cancer

目的探讨中性粒细胞与淋巴细胞比值(NLR)、细胞角蛋白19片段(CYFRA21-1)及人附睾蛋白4(HE4)检测在子宫内膜癌诊断中的应用。方法选取52例子宫内膜癌患者作为子宫内膜癌组,同期收治的50例子宫良性病变患者作为子宫良性病变组。检测两组患者NLR、CYFRA21-1及HE4水平,采用受试者工作特征曲线(ROC)分析上述指标对子宫内膜癌的诊断效能。结果子宫内膜癌组患者的血清NLR、CYFRA21-1及HE4水平均高于子宫良性病变组(P<0.01);ROC曲线分析显示,血清NLR、CYFRA21-1及HE4联合检测子宫内膜癌的诊断效能最高(AUC为0.935),其次为NLR(AUC为0.703)。结论血清NLR、CYFRA21-1及HE4在子宫内膜癌中表达水平较高,三者联合检测时诊断效能最高。

Objective To explore the application of neutrophil to lymphocyte ratio(NLR),cytokeratin fragment 19(CYFRA21-1)and human epididymis protein 4(HE4)in the diagnosis of endometrial cancer.Methods A total of 52 cases with endometrial cancer were selected as the Endometrial Cancer Group while another 50 cases with benign uterine lesions in the same period were selected as the Benign Uterine Lesion Group.The levels of NLR,CYFRA21-1 and HE4 in the two groups were detected,and the diagnostic efficiency of the above indicators for endometrial cancer was analyzed with the receiver operating characteristic curve(ROC).Results The serum NLR,CYFRA21-1 and HE4 levels in the Endometrial Cancer Group were higher than those in the Benign Uterine Lesion Group(P<0.01).The ROC curve analysis showed that the combined detection of NLR,CYFRA21-1 and HE4 had the highest diagnostic efficiency for endometrial cancer(with the AUC of 0.935),followed by the NLR(with the AUC of 0.703).Conclusion The serum NLR,CYFRA21-1 and HE4 levels have a higher expression in the patients with endometrial cancer,and the combined detection of the above indicators has the highest diagnostic efficiency.