非侵入性迷走神经刺激术在创伤后应激障碍中的研究进展

Research Progress of Non-invasive Vagus Nerve Stimulation in Post-traumatic Stress Disorder

创伤后应激障碍(PTSD)是一种高度致残性心理障碍,严重损害个体身心健康,传统药物疗法与心理干预技术的抗PTSD作用有限。非侵入性迷走神经刺激(nVNS)作为一种新兴的神经调节电刺激技术在缓解PTSD症状及其相关情绪障碍上具有积极效应,而这种积极效应的实现主要依赖于nVNS对个体自主神经系统、神经内分泌系统、脑功能以及消退学习能力等多方面的调控。未来研究应深入探讨nVNS抗PTSD作用的潜在机制,并基于多维疗效评价体系推动nVNS与其他心理干预技术的联合应用。

Post-traumatic stress disorder(PTSD)is a highly disabling psychological disorder,which seriously damages the physical and mental health of individuals.However,the anti-PTSD effects of traditional drug therapy and psychological intervention is limited.As an emerging neuromodulatory electrical stimulation technology,non-invasive vagus nerve stimulation(nVNS)has a positive effect in alleviating PTSD symptoms and related mood disorders,and the realization of this positive effect mainly depends on the regulation of nVNS on the individual autonomic nervous system,neuroendocrine system,brain function and extinction learning ability.Future research should further explore the potential mechanism of the anti-PTSD effect of nVNS,and promote the combined application of nVNS and other psychological intervention techniques based on the multi-dimensional efficacy evaluation system.