超低频经颅磁刺激对老年脑梗死后抑郁的效果及对生活质量和脑涨落图仪参数的影响

Curative effect of ultra-low frequency transcranial magnetic stimulation on post-cerebral infarction depression in the elderly and its influences on quality of life and encephalofluctuograph parameters

目的 探讨超低频经颅磁刺激对老年脑梗死后抑郁(PCID)的效果及对生活质量和脑涨落图仪参数的影响。方法 选取石家庄市第八医院收治的100例老年PCID患者作为研究对象,经随机数字表法分为观察组(50例)和对照组(50例)。对照组予以单纯药物治疗,观察组在此基础上予以超低频经颅磁刺激治疗。比较2组临床疗效及治疗前后抑郁情况、神经功能、生活质量、脑涨落图[去甲肾上腺素(NE)、多巴胺(DA)功率值]变化及不良反应。结果 观察组治疗总有效率为90.00%高于对照组74.00%(P<0.05);观察组治疗后汉密尔顿抑郁量表(HAMD)评分、美国国立卫生研究院卒中量表评分低于对照组(P<0.05);观察组治疗后物质生活状态、社会功能、心理功能、躯体功能等维度评分高于对照组(P<0.05);观察组治疗后大脑NE、DA功率高于对照组(P<0.05);2组不良反应比较,差异无统计学意义(P>0.05)。结论 超低频经颅磁刺激能提高PCID的治疗效果,有效改善患者抑郁程度,促进神经功能恢复,提高生活质量,调节脑神经递质,不增加不良反应,安全性高。

Objective To explore the curative effect of ultra-low frequency transcranial magnetic stimulation on post-cerebral infarction depression(PCID)in the elderly and its influences on quality of life and encephalofluctuograph parameters.Methods A total of 100 elderly patients with PCID in the hospital were selected as the research objects.According to random number table method,they were divided into observation group(n=50)and control group(n=50).The control group was given simple drug treatment,while observation group was additionally given ultra-low frequency transcranial magnetic stimulation.The clinical curative effect,depression,nerve function,quality of life,encephalofluctuograph parameters[norepinephrine(NE),dopamine(DA)]and adverse reactions before and after treatment were compared between the two groups.Results The total response rate of treatment in observation group was higher than that in control group(90.00%vs.74.00%,P<0.05).After treatment,HAMD and NIHSS scores in observation group were lower than those in control group(P<0.05),scores of living state,social function,psychological function and physical function were higher than those in control group(P<0.05),and power values of NE and DA were greater than those in control group(P<0.05).The difference in adverse reactions between the two groups was not statistically significant(P>0.05).Conclusions Ultra-low frequency transcranial magnetic stimulation can improve curative effect on PCID,effectively relieve depression,promote the recovery of nerve function,improve quality of life,adjust encephalofluctuograph parameters with less adverse reactions and high safety.