摘要
Oligodendrocytes(OLs)are the only myelinforming cells in the central nervous system.Their differentiation from OL precursor cells(OPCs)occurs throughout life and is mediated by numerous intrinsic and extrinsic factors.OL transcription factor 2(Olig2),a basic helix-loophelix transcription factor,is one of the intrinsic factors that specify the OL lineage.It is expressed by both OPCs and OLs,and no variant of Olig2 has yet been identified in rodents.Although the function of Olig2 in OL maturation and myelination is still under debate.
基金
a Nano Bio Med Young Investigator grant from the University of Saarland(to XB)。
