摘要
Polyglutamine(polyQ) diseases are a group of different neurodegenerative disorders characterized by an abnormal expansion of the trinucleotide cytosine-adenine-guanine(CAG)within coding regions of each disease-associated gene.The abnormal expansion translates into a protein bearing an abnormally long tract of glutamines.
基金
funded by the Portuguese Science and Technology Foundation (FCT) project
by the French Muscular Dystrophy Association(AFM-Téléthon).by the Ataxia UK
by the CureCSB project.AndréConceicao and Rebekah Koppenol are supported by Ph.D.fellowships from FCT (DFA/BD/7892/2020
SFRH/BD/148533/2019,respectively)
