核因子E2相关因子2对创伤性脑损伤的保护作用机制及其靶向治疗药物研究进展

Protective Mechanism of Nrf2 on Traumatic Brain Injury and the Research Progress of Targeted Therapeutic Drugs

创伤性脑损伤(TBI)患者的死亡率和致残率相对较高,为社会和家庭带来极大负担,因此,寻找合适的药物治疗TBI对于降低患者死亡率、改善患者预后具有重要意义。核因子E2相关因子2(Nrf2)是氧化应激信号通路的主要调节因子,已被证明在脑损伤等各种中枢神经系统疾病中具有神经保护作用。本文介绍了Nrf2对TBI的保护作用机制,认为靶向Nrf2治疗TBI具有很大潜力,并总结了靶向Nrf2治疗TBI的药物研究进展,以期为TBI治疗药物的研究与开发提供新思路。

The mortality and disability rate of patients with traumatic brain injury(TBI)is relatively high,which brings a great burden to society and families.Therefore,it is of great significance to find appropriate drug for TBI to reduce the mortality and improve the prognosis of patients.Nuclear factor erythroid 2-related factor 2(Nrf2)is the main regulator of oxidative stress signal pathway and has been proved to have neuroprotective effects in various central nervous system diseases such as brain injury.This paper introduces the protective mechanism of Nrf2 on TBI,considers that targeted Nrf2 has great potential in the treatment of TBI,and summarizes the research progress of drugs targeting Nrf2 in the treatment of TBI,in order to provide new ideas for the research and development of TBI therapeutic drugs.