基于“炎症途径”探讨白头翁汤治疗溃疡性结肠炎的作用机制

Anti-inflammatory Mechanism of Baitouweng Decoction in Treating Ulcerative Colitis Based on"Inflammation Pathway"

溃疡性结肠炎病程缠绵,患者久病损伤脾肾,致脾肾亏虚,加之湿热毒瘀未清,阻滞气血运行,出现瘀血阻络,癥瘕积聚之象。炎症在溃疡性结肠炎的发生、发展和演变中起着重要作用。反复发作的肠道炎症影响黏膜的愈合,肠黏膜不断被破坏和修复,导致腺体变形、数目减少、排列紊乱和萎缩,常形成炎性息肉。白头翁汤清热利湿、凉血解毒、止痢止泻,对于湿热痢疾兼有脓血便者尤为适宜,故可用于治疗溃疡性结肠炎。白头翁汤可能通过调节相关炎症因子水平、调节肠道菌群、介导相关信号通路、调节机体免疫力,从而抑制炎症的反复发作。

Ulcerative colitis has a lingering course,with patients suffering from prolonged illness damaging the Spleen and Kidney,resulting in Spleen and Kidney deficiency.In addition,the Dampness,Heat,toxin,and blood stasis block the circulation of Qi and blood,resulting in blood stasis in meridians and lump accumulation in the body.Inflammation plays an important role in the occurrence,development,and evolution of ulcerative colitis.Recurrent intestinal inflammation affects the healing of the mucosa,which is constantly destroyed and repaired,leading to glandular deformation,decreased number,disordered arrangement,and atrophy,often forming inflammatory polyps.Baitouweng Decoction is particularly suitable for patients with Damp Heat dysentery and purulent and bloody stools,as it can clear Heat and relieve Dampness,cool blood and detoxify,and stop dysentery and diarrhea.Therefore,it can be used to treat ulcerative colitis.Baitouweng Decoction may inhibit the recurrence of inflammation by regulating the levels of related inflammatory factors,regulating intestinal microbiota,mediating related signaling pathways,and regulating the body′s immune system.