药学干预在慢性心力衰竭患者中的应用效果

Application effect of pharmaceutical intervention in patients with chronic heart failure

目的探讨药学干预在慢性心力衰竭患者中的应用效果。方法选取2021年7月至2022年7月中山大学附属第三医院收治的160例慢性心力衰竭患者作为研究对象,采用随机数字表法分为对照组和研究组,每组各80例。对照组应用常规治疗和检查,研究组在此基础上应用药学干预,比较两组患者干预前后的心功能指标变化情况[左室舒张末期内径(LVDd)、N末端脑钠肽前体(NT-proBNP)、左心室射血分数(LVEF)]、生活质量评分情况、再住院率、住院时间以及经济指标变化情况。结果干预前,两组患者的LVDd、NT-proBNP、LVEF水平比较,差异无统计学意义(P>0.05);干预后,两组患者的LVDd、NT-proBNP水平均低于本组干预前,LVEF高于本组治疗前,且研究组的LVDd、NT-proBNP水平低于对照组,LVEF水平高于对照组,差异有统计学意义(P<0.05)。干预前,两组患者的社会限制评分、情绪评分、症状评分比较,差异无统计学意义(P>0.05);干预后,两组患者的社会限制评分、情绪评分、症状评分水平均低于本组干预前,且研究组的社会限制评分、情绪评分、症状评分低于对照组,差异有统计学意义(P<0.05)。研究组总住院费用、药品费用均低于对照组,住院时间短于对照组,再住院率低于对照组,差异有统计学意义(P<0.05)。结论慢性心力衰竭患者应用药学干预效果理想,不仅有利于患者心功能指标的改善,还可以缩短其住院费用和住院时间,降低再住院率,值得推广应用。

Objective To explore the application effect of pharmaceutical intervention in patients with chronic heart failure.Methods A total of 160 patients with chronic heart failure admitted to the Third Affiliated Hospital of Sun Yat-Sen University Yuedong Hospital from July 2021 to July 2022 were selected as research objects,and they were divided into control group and study group according to random number table method,with 80 patients in each group.Routine treatment and examination were performed in the control group,while pharmaceutical intervention was applied in the study group on the basis of which.Changes of cardiac function indexes(left ventricular end diastolic dimension[LVDd],N-terminal pro-B-type natriuretic peptide[NT-proBNP],left ventricularinjection fraction[LVEF])before and after intervention in the two groups were observed and compared,quality of life scores,readmission rates,length of hospital stay,and changes in economic indicators.Results Before intervention,there were no significant differences in LVDd,NT-proBNP and LVEF levels between the two groups(P>0.05).After intervention,LVDd and NT-proBNP levels of the two groups were lower than those before intervention,LVEF was higher than that before treatment,and LVDd and NT-proBNP levels of the study group were lower than those of the control group,LVEF level was higher than that of the control group,the differences were statistically significant(P<0.05).Before intervention,there were no significant differences in social restriction score,emotional score and symptom score between the two groups(P>0.05).After intervention,the social restriction score,emotional score and symptom score of the two groups were lower than those before intervention,and the social restriction score,emotional score and symptom score of the study group were lower than those of the control group,the differences were statistically significant(P<0.05).The total hospitalization cost and drug cost of the study group were lower than that of the control group,the length of hospital stay was shorter than that of the control group,and readmission rate was lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion The effect of pharmaceutical intervention in patients with chronic heart failure is ideal,which is not only conducive to the improvement of patients'cardiac function indicators,but also can shorten the hospitalization cost and length of hospital stay,and reduce the readmission rate,which is worthy of popularization and application.