正念训练对鼻咽癌患者情绪控制及在免疫功能中的作用

Effect of mindfulness training on emotion control and immune function in patients with nasopharyngeal carcinoma

目的分析正念训练对鼻咽癌患者情绪控制和免疫功能的影响。方法选取2019年1月至2020年7月赣州市肿瘤医院收治的96例鼻咽癌患者,按随机数字表法分为常规护理组和正念训练组,每组各48例。常规护理组采用同步放化疗联合常规护理干预,正念训练组在常规护理干预的基础上采用正念训练干预,两组均干预8周。比较两组干预前后的正念注意觉知量表(MAAS)评分及CD4^(+)细胞、CD8^(+)细胞、自然杀伤(NK)细胞与白细胞水平,比较两组干预期间促白细胞增加药物使用情况。结果干预后,两组患者的MAAS评分均高于本组干预前,且正念训练组高于常规护理组,差异有统计学意义(P<0.05);干预后,两组患者的CD4^(+)细胞、NK细胞及白细胞水平均低于本组干预前,CD8^(+)细胞水平均高于本组干预前,差异有统计学意义(P<0.05);干预后,正念训练组患者的CD4^(+)细胞、NK细胞及白细胞水平高于常规护理组,CD8^(+)细胞水平低于常规护理组,差异有统计学意义(P<0.05);干预期间,正念训练组促白细胞增加药物使用率低于对照组,差异有统计学意义(P<0.05)。结论正念训练干预有利于增强鼻咽癌放化疗患者情绪控制能力,减轻放化疗对免疫功能的影响,降低促白细胞增加药物使用率。

Objective To analyze the effects of mindfulness training on emotional control and immune function in patients with nasopharyngeal carcinoma.Methods A total of 96 patients with nasopharyngeal carcinoma admitted to Ganzhou Cancer Hospital from January 2019 to July 2020 were selected and divided into routine nursing group and mindfulness training group according to the random number table method,with 48 cases in each group.The routine nursing group was treated with concurrent chemoradiotherapy combined with routine nursing intervention,and the mindfulness training group was treated with mindfulness training intervention on the basis of routine nursing intervention.Both groups were intervened for 8 weeks.The mindful attention awareness scale(MAAS)score and levels of CD4^(+)cells,CD8^(+)cells,natural killer(NK)cells and white blood cells before and after intervention were compared between the two groups.The use of drugs to promote white blood cell increase during the intervention was compared between the two groups.Results After the intervention,the MAAS scores of the two groups were higher than those before the intervention,and the scores of the mindfulness training group were higher than those of the routine nursing group,and the differences were statistically significant(P<0.05).After the intervention,the levels of CD4^(+)cells,NK cells and white blood cells in the two groups were lower than those before the intervention,and the level of CD8^(+)cells was higher than that before the intervention,and the differences were statistically significant(P<0.05).After intervention,the levels of CD4^(+)cells,NK cells and white blood cells of patients in the mindfulness training group were higher than those in the routine nursing group,and the level of CD8^(+)cells was lower than that in the routine nursing group,and the differences were statistically significant(P<0.05).During the intervention period,the utilization rate of white blood cell promoting drugs in the mindfulness training group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Mindfulness training intervention is beneficial to enhance the emotional control ability of nasopharyngeal carcinoma patients with radiotherapy and chemotherapy,reduce the impact of radiotherapy and chemotherapy on immune function,and reduce the utilization rate of leukocyte-promoting drugs.