柴胡龙骨牡蛎汤联合认知行为疗法治疗肝郁型更年期失眠的疗效分析

Therapeutic efficacy of Chaihu Longgu Muli Decoction combined with cognitive behavioral therapy in liver depression type menopausal insomnia

目的:评价肝郁型更年期失眠应用柴胡龙骨牡蛎汤联合认知行为疗法治疗的疗效。方法:选取2022年1月至2022年9月我院收治的60例肝郁型更年期失眠患者作为研究对象,以随机数表法分为两组,各30例。观察组采用柴胡龙骨牡蛎汤联合认知行为疗法治疗,对照组采用西药阿普唑仑治疗,比较2组患者治疗前后匹兹堡睡眠质量(PSQI)评分、中医证候积分及疗效。结果:治疗后,观察组PSQI评分及中医症候积分均低于对照组,差异有统计学意义(P<0.05);观察组总有效率96.67%,对照组为93.33%,差异无统计学意义(P>0.05)。观察组不良反应发生少于对照组,2组间差异有统计学意义(P<0.05)。结论:柴胡龙骨牡蛎汤联合认知行为疗法治疗肝郁型更年期失眠疗效与阿普唑仑相当;但在改善睡眠质量、减轻疾病症状方面更有效;不良反应发生明显低于服用阿普唑仑片者。

Objective:To evaluate the therapeutic efficacy of Chaihu Longgu Muli Decoction combined with cognitive behavioral therapy(CBT)in liver depression type menopausal insomnia.Methods:Included as study subjects were 60 patients with liver depression type menopausal insomnia admitted to our hospital between January 2022 and September 2022.The subjects were divided into two groups using random number table(n=30 each).The study group was treated with Chaihu Longgu Muli Decoction combined with CBT,while the control group was treated with alprazolam.The two groups were then compared for Pittsburgh Sleep Quality Index(PSQI)score,TCM syndrome score before and after treatment,as well as the therapeutic efficacy.Results:After treatment,the PSQI score and TCM syndrome score were lower in the study group than those in the control group,with statistically significant differences(P<0.05).The total treatment response was 96.67%in the study group vs 93.33%in the control group with no significant difference(P>0.05).The incidence of adverse reactions in the study group was lower compared with the control group,and the difference between groups was statistically significant(P<0.05).Conclusion:Chaihu Longgu Muli Decoction combined with cognitive behavioral therapy is as effective as alprazolam as a treatment of liver depression type menopausal insomnia,and can lead to more improvement in sleep quality and symptom relief with less adverse reactions compared with oral alprazolam.