活体肝移植供者和大样本健康人群生活质量的比较研究

Comparative study of QOL between LDLT donors and large sample healthy populations

目的调查活体肝移植供者健康相关生活质量,并与大样本健康人群做比较。方法采用横断面调查研究设计,基于欧洲五维健康量表(euro quality of life five-dimension questionnaire,EQ-5D-5L)制定调查问卷,采集数据并进行统计分析,具体方法为多个独立样本比较的秩和检验(Kruskal-Wallis H)及两独立样本的非参数检验(Mann-Whitney U秩和检验)。结果本研究中活体肝移植供者共纳入77例活体肝移植供者,男性占比23.4%,女性占比76.6%,平均身高为(161.9±9.0)cm。存在问题最多的是焦虑或沮丧维度,占比68.8%,其次是疼痛或不舒服维度,占比32.5%。问题最少的是自我照顾维度,仅占1.3%。被调查者视觉模拟标尺VAS评分为(77.97±17.78)分。调查数据显示,VAS评分最低为36分,占比1.3%,最高100分,占比9.1%。婚姻状况在自我照顾维度、不同性别在焦虑或沮丧维度上存在显著差异。活体肝移植供者和健康对照人群的行动能力、自我照顾、日常生活维度没有显著差异,而疼痛或不舒服、焦虑或沮丧维度及VAS得分有显著差异,且健康对照人群优于活体肝移植供者。结论活体肝移植供者的健康相关生活质量较好,婚姻、性别是生活质量的影响因素。活体肝移植供者与健康对照人群相比,生活质量存在差距。

Objective A survey was conducted to get some knowledge about the health related quality of life among the population of living donors of liver transplantation.And comparing them with healthy population.Methods Cross-sectional survey design was adopted.The questionnaire was developed based on the European quality of life five-dimension questionaire(EQ-5D-5L),and the data were collected and statistically analyzed.The specific methods were the rank sum test(Kruskal-Wallis H)of multiple independent samples and the non-parametric test(Mann-Whitney U rank sum test)of two independent samples.Results There were totally 77 cases of donors recruited in this study,of which the proportion of males was 23.4%,while the one of female was 76.6%.The average height was(161.9±9.0)cm.There were problems on the dimension of anxiety/depression,and the percentage was 68.8%.Followed by pain/discomfort,with the percentage of 32.5.The least problem was the dimension of self-care,only showing a proportion of 1.3%.The average score of VAS was 77.97±17.78.The variable of marriage showed significant difference on the dimension of self-care.The variable of gender showed significant difference on the dimension of anxiety/depression.With the comparison between the donors and healthy population,the dimension of pain/discomfort,anxiety/depression and VAS have statistical difference.Conclusion The health related QOL of donors was relatively well.The gender and marriage were the impact factors.Comparing to the healthy population,some dimension of QOL has big space to improve.