齐拉西酮注射液联合解郁丸治疗精神分裂症急性期激越症状的效果观察

Observation on the Effect of Ziprasidone Injection Combined with Jieyu Pill in the Treatment of Agitated Symptoms of Schizophrenia in Acute Phase

目的探讨齐拉西酮注射液联合解郁丸治疗精神分裂症急性期激越症状的临床效果。方法选取2019年6月至2020年6月我院收治的120例具有急性期激越症状的精神分裂症患者,随机分为两组各60例。对照组给予齐拉西酮注射液治疗,观察组给予齐拉西酮注射液联合解郁丸治疗。比较两组的急性期激越症状缓解效果、PANSS-EC评分及不良反应。结果观察组的急性期激越症状总缓解率为95.00%,高于对照组的83.33%(P<0.05)。治疗后,两组的PANSS-EC评分均较治疗前降低(P<0.05),且观察组的PANSS-EC评分低于对照组(P<0.05)。观察组的不良反应总发生率为15.00%,低于对照组的30.00%(P<0.05)。结论齐拉西酮注射液联合解郁丸治疗精神分裂症急性期激越症状效果显著,安全性高。

Objective To explore the clinical effect of ziprasidone injection combined with Jieyu pill in the treatment of agitated symptoms of schizophrenia in acute phase.Methods 120 patients with agitated symptoms of schizophrenia in acute phase admitted to our hospital from June 2019 to June 2020 were selected and randomly divided into two groups,with 60 cases in each group.The control group was treated with ziprasidone injection,and the observation group was treated with ziprasidone injection combined with Jieyu pill.The remission effect of agitated symptoms in acute phase,PANSS-EC score and adverse reactions were compared between the two groups.Results The total remission rate of agitated symptoms in acute phase of the observation group was 95.00%,higher than 83.33%of the control group(P<0.05).After treatment,the PANSS-EC scores of the two groups were lower than those before treatment(P<0.05),and the PANSS-EC score of the observation group was lower than that of the control group(P<0.05).The total incidence of adverse reactions of the observation group was 15.00%,lower than 30.00%of the control group(P<0.05).Conclusions Ziprasidone injection combined with Jieyu pill in the treatment of agitated symptoms of schizophrenia in acute phase has significant effect and high safety.