童康片治疗儿童反复呼吸道感染的Meta分析

Meta-analysis of Tongkang Tablets in treatment of recurrent respiratory tract infections in children

目的分析评价童康片单用及联合化学药治疗儿童反复呼吸道感染的临床疗效及安全性。方法使用计算机对中英文数据库,包括中国学术期刊全文数据库(CNKI)、维普中文期刊全文数据库(VIP)、万方数据库(Wanfang Data)、中国生物医学文献数据库(CBM)、Cochrane Library、PubMed和Web of Science进行文献检索,收集各数据库建库起至2022年12月2日童康片单用及联合化学药治疗儿童反复呼吸道感染的临床随机对照试验(RCT),使用RevMan 5.4软件进行Meta分析。结果共纳入13项RCTs、包括1411例患儿。Meta分析结果显示:试验组总有效率高于对照组[RR=1.25,95%CI(1.19,1.31),P<0.00001],且童康片单用及联合化学药的差异没有统计学意义;治疗后两组免疫球蛋白IgA[MD=−0.05,95%CI(−0.48,0.37),P=0.80]、IgG[MD=−0.16,95%CI(−0.95,0.62),P=0.68]、IgM[MD=0.02,95%CI(−0.32,0.37),P=0.90]、不良反应率[RR=0.80,95%CI(0.23,2.80),P=0.73]比较,差异无统计学意义。结论童康片可提高治疗儿童反复呼吸道感染的疗效,且单用或联合化学药对其有效率影响不大,对IgA、IgG、IgM及不良反应发生情况没有明显影响。

Objective To analyze and evaluate the clinical efficacy and safety of Tongkang Tablets alone and in combination with chemical drugs in the treatment of recurrent respiratory tract infections in children.Methods Data were electronically searched from CNKI,CBM,VIP,Wanfang Database,Cochrane Library,PubMed and Web of Science,from the date of establishment to December 2,2022,for the randomized controlled trial(RCT)of Tongkang Tablets alone and in combination with chemical drugs in the treatment of recurrent respiratory tract infections in children,and analyzed the data using RevMan 5.4 software.Results A total of 13 RCTs involving 1411 children were included.The Meta-analysis results showed that the total effective rate of the experimental group was higher than that of the control group[RR=1.25,95%CI(1.19,1.31),P<0.00001],and the difference between Tongkang Tablets alone and combined chemical drugs was not statistically significant.After treatment,the two groups of immunoglobulins IgA[MD=−0.05,95%CI(−0.48,0.37),P=0.80],IgG[MD=−0.16,95%CI(−0.95,0.62),P=0.68],IgM[MD=0.02,95%CI(−0.32,0.37),P=0.90],adverse reaction rate[RR=0.80,95%CI(0.23,2.80),P=0.73]were compared,the difference was not statistically significant.Conclusion Tongkang Tablets can improve the efficacy of treating recurrent respiratory tract infections in children,and the efficacy of single or combined chemical drugs has little effect,and there is no significant effect on the occurrence of IgA,IgG,IgM and adverse reactions.