锌诱导神经毒性损伤机制研究进展

Research Progress on Mechanism of Zinc-Induced Neurotoxic Injury

锌是存在于动物和人类中枢神经系统(CNS)第二丰富的微量元素,是维持脑功能所必需的调控因子,因此在动物饲料和人类食物中必不可少。然而,锌也是一种潜在有毒金属,其平衡失调与神经疾病的发病机制密切相关。过量的锌会诱导神经元氧化应激、线粒体损伤和炎症反应,最终通过凋亡和自噬诱发神经元死亡。本文对锌的神经毒性及其作用机制的研究进展进行综述,以期为锌稳态失调引起疾病的深入研究提供参考。

Zinc is the second most abundant trace element found in the central nervous system(CNS)of humans and animals.As a regulator necessary for maintaining brain function,zinc is essential for human and animal food.However,zinc is also a potentially toxic metal,and its imbalance is closely related to the pathogenesis of neurological diseases.Excessive zinc may induce oxidative stress,mitochondrial damage and inflammatory response in neurons,and lead to neuronal death through apoptosis and autophagy.By presenting an overview on the research status of zinc neurotoxicity and the possible mechanism of zinc induced neurotoxicity,this paper provides reference for further study of diseases caused by zinc homeostasis.