健脾补肾强骨合剂治疗2型糖尿病合并骨质疏松脾肾阳虚夹瘀证临床疗效观察及对骨代谢指标的影响

Clinical Observation of Jianpi Bushen Qianggu Mixture on Type 2Diabetic Osteoporosis of Spleen-Kidney-Yang Deficiency with Stasis Syndrome and Its Influence on Markers of Bone Metabolism

目的:通过观察健脾补肾强骨合剂治疗2型糖尿病合并骨质疏松脾肾阳虚夹瘀证临床疗效和对骨代谢指标的影响,探讨健脾补肾强骨合剂治疗2型糖尿病合并骨质疏松症的有效性和安全性。方法:选择符合2型糖尿病合并骨质疏松脾肾阳虚夹瘀证纳入标准的患者60例,按随机数字表法将受试者分为治疗组和对照组(各30例),对照组患者在基础治疗、常规降糖治疗的基础上给予碳酸钙D3片,治疗组患者在对照组治疗方法基础上给予健脾补肾强骨合剂,比较两组患者临床疗效。结果:治疗组患者临床症状改善明显,优于对照组患者(P<0.05),治疗组患者临床疗效更显著(P<0.05),治疗后患者血钙、血磷均有所升高(P<0.05),治疗组患者空腹血糖、餐后2 h血糖均明显降低(P<0.05),骨密度增加(P<0.05),治疗后治疗组患者骨代谢指标改善,碱性磷酸酶、骨钙素、25羟维生素D增加更明显(P<0.05),甲状旁腺激素降低更明显(P<0.05)。结论:健脾补肾强骨合剂治疗2型糖尿病合并骨质疏松脾肾阳虚夹瘀证,能改善患者脾肾阳虚夹瘀证临床症状,降低血糖水平,提高骨密度,改善骨代谢指标。健脾补肾强骨合剂治疗2型糖尿病合并骨质疏松安全、高效,应用前景广阔。

Objective:To investigate the clinical therapeutic effect of jianpi bushen qianggu mixture on type 2diabetic osteoporo-sis with spleen-kidney yang deficiency and blood stasis syndrome and its influence on Markers of bone metabolism,evaluate the effectiveness and safety of jianpi bushen qianggu mixture.Methods:In this study,60patients with type 2diabetes mellitus complicated with osteoporosis with spleen-kidney yang deficiency and blood stasis syndrome were selected and randomly divid-ed into treatment group and control group(30cases in each group).The control group was given calcium carbonate D3tablets on the basis of basic treatment and routine hypoglycemic treatment,and the treatment group was given the jianpi bushen qiang-gu mixture on the basis of the control group.The clinical curative effects of the two groups were observed and compared.Results:The improvement of clinical symptoms in the treatment group was significantly better than that in the control group(P<0.05),the clinical efficacy of the treatment group was more significant(P<0.05),patients'blood calcium and phosphor-us increased after treatment(P<0.05),and patients in the treatment group had significantly lower fasting blood glucose and 2-hour postprandial blood glucose(P<0.05),bone density increased(P<0.05),bone metabolism markers improved in the treatment group after treatment,alkaline phosphatase,osteocalcin and 25hydroxyvitamin D increased more significantly(P<0.05),and parathyroid hormone decreased more significantly(P<0.05),and the differences were statistically significant.Conclusion:Jianpi bushen qianggu mixture in the treatment of type 2diabetes osteoporosis with spleen and kidney yang defi-ciency and stasis syndrome can significantly reduce the patient's TCM syndrome score and improve the clinical symptoms of spleen and kidney yang deficiency and stasis syndrome,it can significantly reduce blood glucose levels,increase bone mineral density,and improve bone metabolism indicators,jianpi bushen qianggu mixture is safe and efficient in the treatment of type 2 diabetes osteoporosis,and has broad application prospects.