基于数据挖掘技术的肝硬化腹水辨证处方规律分析

Analysis of the Prescription Law of Liver Cirrhosis Ascites Based on Data Mining Technology

目的:检索中国知网(CNKI)文献,分析中药治疗肝硬化腹水组方规律。方法:检索CNKI中药治疗肝硬化腹水文献,建立数据库并导入IBM SPSS Statistics 25,进行证型、高频药物、性味归经和关联规则、聚类分析。结果:共纳入中药复方465个,共出现233味中药,脾肾阳虚水停证、脾虚水停证频次最高,药物归经前5位分别为肝、肺、胃、脾、肾,药性主要为寒、温,药味以苦、甘、辛居多,关联规则分析显示,茯苓-白术为核心药对,对频次>100次的中药进行聚类分析后,共得到药物组合3组。结论:健脾益气、化瘀利水为肝硬化腹水的基本治则,治疗以扶正为本、逐水为标,用药当以补益为先,兼用理气、清热、温中等法随证治之,其中气滞水停证和脾虚水停证多加用止咳化痰药以达“提壶揭盖”之效,寒温并用,诸脏并调。

Objective:Analyzing the prescription rules of documents in CNKI for the Treatment of Liver Cirrhosis Ascites.Methods:Search the CNKI literature on the treatment of liver cirrhosis ascites with traditional Chinese medicine,then establish a database and import it into IBM SPSS Statistics 25for syndrome type,high-frequency drugs,nature and taste tropism,associ-ation rules,and cluster analysis.Results:A total of 465traditional Chinese medicine prescriptions were included,and 233tradi-tional Chinese medicines appeared in total.The most syndrome types were water stop due to spleen and kidney yang deficien-cy,and water stop due to spleen deficiency.The first five drug meridians were liver,lung,stomach,spleen,and kidney respec-tively.Cold and warm were the main drug properties.And the drug flavors were mostly bitter,sweet,and spicy.Association rule analysis showed that fu ling-bai zhu was the core drug pair.Three groups of drug combinations were obtained after cluster analysis of Chinese medicines with a frequency greater than 100.Conclusion:The basic treatment principle of ascites due to liver cirrhosis is to invigorate the spleen and replenish qi,remove blood stasis,and promote water.The treatment is based on strengthe-ning the body's integrity and driving out the water.The drug should be used first to invigorate the body,and the methods of regu-lating Qi,clearing heat,and warming the body should be used along with the syndrome.The syndrome of Qi stagnation and water stagnation and the syndrome of spleen deficiency is mostly treated with antitussive and expectorant drugs to achieve the effect of“lifting the kettle and uncovering the lid”.Cold and warm are used together,and the viscera are adjusted together.