摘要
目的 探讨血小板平均体积(mean platelet volume, MPV)和血清胱抑素C(Cystatin C,CysC)检测对急性感染诱发急性心肌梗死(acute myocardial infarction, AMI)的临床诊断意义。方法 选取周口市第一人民医院2020年11月至2021年11月共128例急性感染患者,根据是否诱发AMI分为梗死组和未梗死组。检测两组MPV与CysC水平,分析两者在临床中的诊断价值。进行多因素logistic回归分析诱发心肌梗死的危险因素。结果 梗死组年龄以及糖尿病、高血压、冠心病、高脂血发病率均高于未梗死组,差异有统计学意义(P<0.05)。梗死组MPV、CysC水平均高于未梗死组,差异有统计学意义(P<0.05)。ROC曲线分析结果发现,MPV的曲线下面积为(AUC=0.731,95%CI:0.645~0.818);CysC去线下面积为(AUC=0.671,95%CI:0.578~0.765)。MPV、CysC与急性感染诱发AMI均呈负相关性(P<0.05)。多因素logistic回归分析表明年龄大,有糖尿病、高血压、冠心病、高血脂,且MPV、CysC含量高的患者,发生心肌梗死的危险性大。结论 MPV和CysC检测在急性感染诱发AMI的临床诊断中均具有一定的应用价值,临床中应重点关注高风险的急性感染患者,包括高龄以及合并糖尿病、高血压、冠心病、高脂血症等基础疾病的患者,遵循早诊断、早治疗的原则,从而改善患者预后,保证患者的生命安全。
Objective To explore the clinical diagnostic significance of mean platelet volume(MPV) and serum Cystatin C(CysC) for acute infection-induced acute myocardial infarction(AMI). Methods A total of 128 patients with acute infection in Zhoukou City First People’s Hospital from November 2020 to November 2021 were selected and divided into infarct group and non-infarct group according to whether AMI was induced. Detect the levels of MPV and CysC in the two groups, and analyze their clinical diagnostic value. Results The age and the incidence of diabetes, hypertension, coronary heart disease, and hyperlipemia in the infarct group were higher than those in the non-infarct group, and the difference was statistically significant(P<0.05). The MPV and CysC levels in the infarct group were higher than those in the non-infarct group, and the difference was statistically significant(P<0.05). ROC curve analysis showed that the area under the curve of MPV was(AUC=0.731, 95% CI: 0.645-0.818);The area under the CysC line was(AUC=0.671, 95% CI: 0.578-0.765). MPV and CysC were negatively correlated with acute infection-induced AMI(P<0.05). Conclusion MPV and CysC detection have certain application value in the clinical diagnosis of acute infection-induced AMI. In clinical practice, we should focus on high-risk acute infection patients, including the elderly and those with diabetes, hypertension, coronary heart disease, and hyperlipidemia. For patients with basic diseases, follow the principles of early diagnosis and early treatment, so as to improve the prognosis of patients and ensure the safety of patients’ lives.
作者
陈廷春
CHEN Ting-chun(Department of Cardiovascular Medicine,Zhoukou the First People’s Hospital,Zhoukou,Henan 466700,China)
出处
《医药论坛杂志》
2023年第4期44-47,共4页
Journal of Medical Forum
关键词
血小板平均体积
胱抑素C
急性感染
急性心肌梗死
临床诊断
Mean platelet volume
Cystatin C
Acute infection
Acute myocardial infarction
Clinical diagnosis