妊娠期高血压疾病患者病情程度与血常规和凝血指标的相关性分析

Correlation analysis between degree of illness and blood routine and coagulation indexes in patients with gestational hypertension

目的 分析妊娠期高血压病(HDCP)患者病情程度和血常规以及凝血指标之间的关系。方法 选取2021年1月—2021年12月单县东大医院有限公司收治的HDCP患者总共76例设为观察组,另选取同时间段本院80例健康孕妇设为对照组,比较两组凝血酶原时间(PT)、活化部分的凝血酶原时间(APTT)、纤维蛋白原(Fib)、D-二聚体(D-D)、凝血酶原活动度(PTA)及国际标准化比值(INR)等凝血指标水平,红细胞计数(RBC)、红细胞压积(Hct)、血红蛋白(Hb)、血小板计数(PLT)、红细胞体积的分布宽度(RDW)、平均血小板体积(MPV)、血小板体积的分布宽度(PDW)、血小板和淋巴细胞比值(PLR)等血常规指标水平,同时结合病情程度将观察组分成妊娠期高血压组、子痫前期组,比较两组各项血常规和凝血指标差异,分析HDCP患者病情程度和各项指标间的关系。结果 观察组RBC、Hct、Hb、PLT、PLR、PT、INR、APTT水平低于对照组,RDW、MPV、PDW、PTA、Fib、DD水平高于对照组(P<0.05)。观察组中子痫前期组RBC、Hct、Hb、PLT、PLR、PT、INR、APTT水平低于妊娠期高血压组,RDW、MPV、PDW、PTA、Fib、DD水平高于妊娠期高血压组(P<0.05)。相关性分析发现,HDCP患者病情程度和RBC、Hct、Hb、RDW、MPV、PDW、PTA、Fib、DD之间为负相关关系,和PLT、PLR、PT、INR、APTT之间为正相关关系。结论 HDCP患者病情程度和血常规及凝血指标有关,上述指标能被应用到监测HDCP患者的病情进展中。

Objective To analyze the relationship between the severity of pregnancy induced hypertension(HDCP) and blood routine and coagulation indexes.Methods A total of 76 patients with HDCP treated in our hospital from January 2021 to December 2021 were selected as the observation group, and 80 healthy pregnant women in our hospital at the same time were selected as the control group.The levels of coagulation indexes such as prothrombin time(PT),activated prothrombin time(APTT),fibrinogen(Fib),D-Dimer(D-D),prothrombin activity(PTA) and international standardized ratio(INR),and the levels of blood routine indexs such as red blood cell count(RBC),hematocrit(Hct),hemoglobin(Hb),platelet count(PLT),red blood cell volume distribution width(RDW),mean platelet volume(MPV),platelet volume distribution width(PDW),platelet to lymphocyte ratio(PLR) were compared between the two groups.At the same time, combined with the degree of illness, the observation group was divided into pregnancy induced hypertension group and preeclampsia group.The differences of blood routine and coagulation indexes between the two groups were compared, and the relationship between the severity of HDCP patients and various indexes was analyzed.Results The levels of RBC,Hct, Hb, PLT,PLR,PT,INR and APTT in the observation group were lower than those in the control group, and the levels of RDW,MPV,PDW,PTA,Fib and D-D in the observation group were higher than those in the control group(P<0.05).The levels of RBC,Hct, Hb, PLT,PLR,Pt, INR and APTT in preeclampsia group were lower than those in gestational hypertension group, and the levels of RDW,MPV,PDW,PTA,Fib and D-D in preeclampsia group were higher than those in gestational hypertension group(P<0.05).Correlation analysis showed that the degree of HDCP patients’ condition was negatively correlated with RBC,Hct, Hb, RDW,MPV,PDW,PTA,Fib and D-D,and positively correlated with PLT,PLR,Pt, INR and APTT.Conclusion The disease degree of HDCP patients is related to blood routine and coagulation indexes.The above indexes can be applied to monitor the disease progress of HDCP patients.