CA724、CEA、CA242、CA199肿瘤标志物联合检验在胃癌中的诊断价值分析

Analysis of the Diagnostic Value of Combined Detection of CA724,CEA,CA242,CA199 Tumor Markers in Gastric Cancer

目的分析CA724、CEA、CA242、CA199肿瘤标志物联合检验在胃癌中的诊断价值。方法选取2021年1月—2022年3月齐齐哈尔医学院附属第二医院收治的41例胃癌患者为研究组,同期收治的41例慢性萎缩性胃炎伴重度不典型增生患者为对照组a,同期收治的41例胃黏膜检查正常或浅表性胃炎患者为对照组b。比较3组CA724、CEA、CA242、CA199肿瘤标志物水平。结果研究组肿瘤标志物CA724、CEA、CA242、CA199水平均显著高于对照组a、对照组b,且对照组a高于对照组b,差异有统计学意义(P<0.05)。低分化程度胃癌患者CA724、CEA、CA242、CA199阳性率分别为64.00%、68.00%、76.00%、64.00%,均高于高、中分化程度胃癌患者,差异有统计学意义(χ^(2)=8.034、12.085、10.304、4.188,P<0.05)。肝转移胃癌患者血清CA724、CEA、CA242、CA199符合率均高于无肝转移患者,差异有统计学意义(P<0.05)。临床分期为Ⅲ期、Ⅳ期的胃癌患者血清CA724、CEA、CA242、CA199符合率均高于Ⅰ~Ⅱ期患者,差异有统计学意义(P<0.05)。结论CA724、CEA、CA242、CA199肿瘤标志物联合检验对于胃癌的临床诊断具有积极辅助作用。

Objective Analysis of the diagnostic value of combined detection of CA724,CEA,CA242,CA199 tumor markers in gastric cancer.Methods A total of 41 gastric cancer patients who were admitted to the Second Affiliated Hospital of qigiher Medical College from January 2021 to March 2022 were selected as the study group,a total of 41 chronic atrophic gastritis patients with severe dysplasia who were admitted to the same period as the control group a,and 41 gastric mucosal examination normal or superficial gastritis patients who were admitted to the same period as the control group b.Tumor marker levels of CA724,CEA,CA242,and CA199 were compared among the 3 groups.Results The levels of tumor markers CA724,CEA,CA242,and CA199 in the study group were significantly higher than in the control group a and control group,and the control group a higher than in the control group b,the difference was statistically significant(P<0.05).The positive rates of CA724,CEA,CA242,and CA199 in poorly differentiated gastric cancer patients were 64.00%,68.00%,76.00%,and 64.00%higher than those in well-and moderately differ⁃entiated gastric cancer patients,the difference was statistically significant(χ^(2)=8.034,12.085,10.304,4.188,P<0.05).The compliance rates of serum CA724,CEA,CA242 and CA199 in gastric cancer patients with liver metastasis were higher than those in patients without liver metastasis,the difference was statistically significant(P<0.05).The compli⁃ancerates of serum CA724,CEA,CA242,and CA199 in gastric cancer patients with clinical stagesⅢandⅣwere higher than those in patients with clinical stagesⅠ-Ⅱ,the difference was statistically significant(P<0.05).Conclusion CA724,CEA,CA242,CA199 tumor marker combined detection has a positive auxiliary effect on the clinical diagnosis of gastric cancer.