头孢哌酮钠舒巴坦钠联合替加环素治疗多重耐药菌重症肺炎的效果分析

Effect of Cefoperazone Sodium and Sulbactam Sodium Combined with Tigacycline for Treatment of Severe Pneumonia with Multidrug-resistant Bacteria

目的探讨头孢哌酮钠舒巴坦钠(cefoperazone sodium and sulbactam sodium,CSSS)联合替加环素(tigacycline,TG)治疗多重耐药菌重症肺炎的疗效。方法选取2020年1月—2022年6月苏州市吴中人民医院收治的72例重症肺炎患者为研究对象,随机分成两组,各36例。对照组单纯以CSSS抗菌治疗,观察组在对照组基础上联合TG抗菌治疗。对比两组患者症状改善、疗效、抗菌效果、不良反应。结果观察组治疗总有效率91.67%,高于对照组的66.67%,差异有统计学意义(χ^(2)=6.821,P<0.05)。观察组清除率80.56%,高于对照组的58.33%,差异有统计学意义(χ^(2)=4.189,P<0.05);观察组体温复常、胸片正常、啰音消失、住院时间为(5.49±1.92)、(12.58±3.92)、(10.83±2.71)、(16.71±5.16)d低于对照组的(7.27±2.36)、(16.14±4.23)、(13.41±2.76)、(20.67±5.47)d,差异有统计学意义(t=3.510、3.704、4.000、3.160,P<0.05);观察组不良反应发生率为8.33%,对照组发生率为5.56%,差异无统计学意义(P>0.05)。结论CSSS联合TG在治疗多重耐药菌重症肺炎具有良好的疗效和抗菌效果,可缩短患者病程,同时联合用药安全性也能保障,不良反应风险低。

Objective To investigate the efficacy of cefoperazone sodium and sulbactam sodium(CSSS)combined with tigacycline(TG)in the treatment of severe pneumonia caused by multidrug-resistant bacteria.Methods A total of 72 patients with severe pneumonia admitted to Suzhou Wuzhong People's Hospital from January 2020 to June 2022 were randomly divided into two groups,with 36 patients in each group.The control group was treated with antibacterial CSSS alone,and the observation group was treated with antibacterial TG on the basis of the control group.Symptom improvement,therapeutic efficacy,antibacterial effect and adverse reactions were compared between the two groups.Results The total effective rate of observation group was 91.67%,which was higher than that of control group(66.67%),the difference was statistically significant(χ^(2)=6.821,P<0.05).The clearance rate of observation group was 80.56%,which was higher than that of control group(58.33%),the difference was statistically significant(χ^(2)=4.189,P<0.05).In the observation group,the body temperature returned to normal,the chest radiograph was normal,the rales disappeared,the length of hospitalization was(5.49±1.92)d,(12.58±3.92)d,(10.83±2.71)d,(16.71±5.16)d,lower than the control group(7.27±2.36)d,(16.14±4.23)d,(13.41±2.76)d,(20.67±5.47)d,the difference was statistically significant(t=3.510,3.704,4.000,3.160,P<0.05).The incidence of adverse reactions was 8.33%in the observation group and 5.56%in the control group,the difference was not statistically significan(P>0.05).Conclusion CSSS com⁃bined with TG has good curative effect and antibacterial effect in the treatment of severe pneumonia with multidrug resistant bacteria,which can shorten the course of the disease of patients.Meanwhile,the safety of combined medica⁃tion can be guaranteed with low risk of adverse reactions.