左氧氟沙星与头孢呋辛在呼吸道感染中的临床价值对比

Comparison of Clinical Value of Levofloxacin and Cefuroxime in Respiratory Tract Infections

目的探讨左氧氟沙星与头孢呋辛在呼吸道感染中的临床价值。方法选取2019年6月—2021年6月南京农业大学校医院收治的初诊呼吸道感染患者100例为研究对象,按照随机数表法分为观察组和对照组,各50例。对照组使用左氧氟沙星,观察组使用头孢呋辛。比较两组患者临床症状与生化指标恢复时间,临床症状及体征消失时间,统计两组耐药性发生率、治疗后更换抗生素比例及不良反应发生情况。结果观察组体温恢复正常时间、C反应蛋白水平恢复正常时间及白细胞恢复正常时间均显著比对照组短,差异有统计学意义(P<0.05);观察组咳嗽咳痰消失时间、鼻塞流涕消失时间和咽痛消失时间均显著比对照组短,差异有统计学意义(P<0.05);观察组耐药性发生率及治疗后更换抗生素比例均低于对照组,差异有统计学意义(χ^(2)=8.274、7.111,P<0.05);观察组发生皮疹、腹痛腹泻、恶心呕吐和头晕比例(2.0%)低于对照组(26.0%),差异有统计学意义(χ^(2)=11.960,P<0.05)。结论针对呼吸道感染患者使用头孢呋辛治疗,具有临床效果可靠,较快改善患者临床症状与体征,不良反应少等特点。

Objective To explore the clinical value of levofloxacin and cefuroxime in respiratory tract infection.Methods 100 patients with respiratory tract infection admitted to the University Hospital of Nanjing Agricultural Uni⁃versity from June 2019 to June 2021 were selected as the study subjects.They were divided into the observation group and the control group according to the random number table method,with 50 cases each.Levofloxacin was used in the control group and cefuroxime was used in the observation group.The time of recovery of clinical symptoms and bio⁃chemical indexes,and the time of disappearance of clinical symptoms and signs were compared between the two groups.The recovery time of clinical symptoms and biochemical indicators,the disappearance time of clinical symp⁃toms and physical signs of the two groups were compared,and the occurrence rate of drug resistance,the proportion of antibiotic replacement after treatment and the occurrence of adverse reactions were counted.Results The recovery time of body temperature,C-reactive protein level and white blood cells in the observation group were significantly shotter than those in the control group,the difference was statistically significant(P<0.05);the disappearance time of cough and expectoration,nasal obstruction and runny nose and pharyngalgia in the observation group were signifi⁃cantly shorter than those in the control group,the difference was statistically significant(P<0.05);the incidence of drug resistance and the proportion of antibiotic replacement after treatment in the observation group were signifi⁃cantly lower than those in the control group,the difference was statistically significant(χ^(2)=8.274,7.111,P<0.05);the proportion of rash,abdominal pain and diarrhea,nausea,vomiting and dizziness in the observation group(2.0%)was lower than that in the control group(26.0%),and the difference was statistically significant(χ^(2)=11.960,P<0.05).Conclusion The use of cefuroxime for the treatment of patients with respiratory tract infections has reliable clinical effects,faster improvement of patients'clinical symptoms and signs,and fewer adverse effects.