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艾拉莫德联合硫酸氨基葡萄糖治疗骨关节炎的临床疗效及对患者软骨代谢的影响 被引量:2

Clinical Efficacy of Iguratimod Combined with Glucosamine Sulfate in the Treatment of Knee Osteoarthritis and Its Effects on Cartilage Metabolism of Patients
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摘要 目的:研究艾拉莫德联合硫酸氨基葡萄糖治疗骨关节炎(OA)的效果。方法:将2021年1月至2022年3月于中国人民解放军中部战区总医院就诊的167例OA患者,按随机数字表法分为联合组(85例)和对照组(82例)。对照组患者使用硫酸氨基葡萄糖治疗,1次250 mg,1日3次。联合组患者在对照组的基础上加用艾拉莫德,1次25 mg,1日2次。连续治疗8周后,比较两组患者的临床疗效,并对患者的西安大略和麦马斯特大学骨关节炎指数(WOMAC)、视觉模拟评分(VAS)及实验室检验结果[红细胞沉降率(ESR)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)及基质金属蛋白酶13(MMP-13)]进行统计分析。结果:治疗后,联合组患者的总有效率为92.94%(79/85),明显高于对照组的79.27%(65/82),差异有统计学意义(P<0.05)。两组患者治疗后的WOMAC及VAS评分均明显降低,ESR、TNF-α、IL-6和MMP-13水平明显改善,且联合组治疗效果优于对照组,差异均有统计学意义(P<0.05)。结论:艾拉莫德联合硫酸氨基葡萄糖可缓解OA患者的膝关节疼痛,改善关节功能和活动度,减轻滑膜炎症,调节软骨代谢。 OBJECTIVE:To study the effect of iguratimod combined with glucosamine sulfate in the treatment of knee osteoarthritis(OA).METHODS:A total of 167 patients with OA admitted into the General Hospital of Central Theater Command of PLA from Jan.2021 to Mar.2022 were selected and divided into the combined group(85 cases)and control group(82 cases)via random number table method.The control group was treated with glucosamine sulfate,250 mg each time and 3 times a day.The combined group was given iguratimod based on the control group,25 mg each time and twice a day.After 8 weeks of continuous treatment,the clinical efficacy was compared between two groups,the Western Ontario and McMaster University Osteoarthritis Index(WOMAC),visual analog score(VAS)and laboratory test results[erythrocyte sedimentation rate(ESR),tumor necrosis factorα(TNF-α),interleukin 6(IL-6)and matrix metalloproteinase 13(MMP-13)]of the patients were statistical analysis.RESULTS:After treatment,the overall effective rate of the combined group was 92.94%(79/85),which was significantly higher than that of the control group(79.27%,65/82),with statistically significant difference(P<0.05).After treatment,the WOMAC and VAS scores of both groups were significantly reduced,the ESR,TNF-α,IL-6 and MMP-13 levels were significantly improved,and the treatment effect of the combined group was better than that of the control group,with statistically significant differences(P<0.05).CONCLUSIONS:Iguratimod combined with glucosamine sulfate can relieve knee pain,improve joint function and mobility,reduce synovial inflammation and regulate cartilage metabolism for patients with OA.
作者 张钰景 陈利锋 陈建华 ZHANG Yujing;CHEN Lifeng;CHEN Jianhua(School of Medicine,Wuhan University of Science and Technology,Wuhan 430006,China;Dept.of Rheumatology and Immunology,General Hospital of Central Theater Command of PLA,Wuhan 430070,China)
出处 《中国医院用药评价与分析》 2023年第4期404-406,411,共4页 Evaluation and Analysis of Drug-use in Hospitals of China
基金 湖北省自然科学基金项目(No.2020CFB595) 中部战区总医院育英计划项目(No.ZZYFH202118)。
关键词 骨关节炎 艾拉莫德 临床性研究 软骨代谢 Knee osteoarthritis Iguratimod Clinical study Cartilage metabolism
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