氨咖黄敏胶囊对精神障碍患者感冒期间氯氮平血药浓度的影响

Effects of Paracetamol,Caffeine,Bovis Calculus Sativus and Chlorphenamine Maleate Capsules(Ankahuangmin Capsules)on Blood Concentration of Clozapine in Patients with Mental Disorder During Cold

目的:探讨氨咖黄敏胶囊对精神障碍患者感冒期间氯氮平血药浓度的影响。方法:回顾性收集2020年1月至2021年10月该院进行氯氮平稳定治疗并伴有感冒期间服用氨咖黄敏胶囊的44例精神障碍住院患者的病历资料,获取患者的性别、年龄、服药方案、联合用药和氯氮平血药浓度等信息,使用SPSS 25.0软件进行统计分析。结果:44例患者在合用氨咖黄敏胶囊后氯氮平血药浓度有不同程度的升高,基线期平均血药浓度为(444.23±289.24)ng/mL,干预期平均血药浓度为(621.43±375.23)ng/mL;白细胞计数(WBC)也出现了不同程度的升高,基线期WBC水平中位值为6.67×10^(9)/L,感冒期WBC水平中位值为8.06×10^(9)/L;12例患者发生了氯氮平血药浓度升高后的不良反应。结论:感冒期间使用氨咖黄敏胶囊对氯氮平血药浓度升高有影响,WBC水平升高不能显著影响氯氮平血药浓度。氨咖黄敏胶囊与氯氮平联合应用时,对氯氮平血药浓度的监测至关重要,以避免发生与氯氮平血药浓度相关的不良反应。

OBJECTIVE:To probe into the effects of Paracetamol,caffeine,bovis calculus sativus and chlorphenamine maleate capsules(Ankahuangmin capsules)on blood concentration of clozapine in patients with mental disorder during cold.METHODS:Medical records of 44 inpatients with mental disorders who underwent stable treatment with clozapine and took Paracetamol,caffeine,bovis calculus sativus and chlorphenamine maleate capsules(Ankahuangmin capsules)during cold from Jan.2020 to Oct.2021 in the hospital were retrospectively collected to obtain information on patients’gender,age,dosing regimen,drug combination and blood concentration of clozapine,and statistical analysis was performed by using SPSS 25.0.RESULTS:The blood concentration of clozapine increased to different degrees in 44 patients treated with Paracetamol,caffeine,bovis calculus sativus and chlorphenamine maleate capsules(Ankahuangmin capsules),the mean blood concentration was(444.23±289.24)ng/mL at baseline period and(621.43±375.23)ng/mL at intervention period;the white blood cell count(WBC)also increased to different degrees,the median value of WBC was 6.67×10^(9)/L at baseline period and 8.06×10^(9)/L at cold period;12 patients experienced adverse drug reactions after blood concentration elevation of clozapine.CONCLUSIONS:The application of Paracetamol,caffeine,bovis calculus sativus and chlorphenamine maleate capsules(Ankahuangmin capsules)during the cold period has an effect on blood concentration elevation of clozapine,while the elevation of WBC could not significantly affect the blood concentration of clozapine.The monitoring on blood concentration of clozapine after drug combination of Paracetamol,caffeine,bovis calculus sativus and chlorphenamine maleate capsules(Ankahuangmin capsules)and clozapine is crucial to avoid adverse drug reactions related to blood concentration of clozapine.