慢性阻塞性肺疾病患者血清基质金属蛋白酶-9和金属蛋白酶抑制剂-1的表达及其对肺血管重塑的预测价值

Relationship between serum matrix metalloproteinase⁃9 and metalloproteinase⁃1 expression in patients with chronic obstructive pulmonary disease and their predictive value for pulmonary vascular remodeling

目的探讨基质金属蛋白酶-9(matrix metalloproteinase,MMP-9)、基质金属蛋白酶抑制剂-1(matrix metalloproteinase inhibitor,TIMP-1)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者血清中表达的相关性及其对肺血管重塑(pulmonary vascular remodeling,PVR)的预测价值。方法选取2019年1月至2021年12月住院治疗的COPD患者1091例作为研究对象,根据临床诊断将患者分为急性加重期组和稳定期组,对COPD患者血清MMP-9、TIMP-1表达水平进行比较,对统计结果进行相关性分析。并对患者血清MMP-9、TIMP-1表达与肺血管重塑预测的特异性进行比较。结果急性加重期COPD患者血清MMP-9、TIMP-1相对表达量均显著高于稳定期组患者(P<0.01)。经Pearson相关性分析,MMP-9、TIMP-1在COPD患者血清中表达呈显著正相关。肺血管重塑发生患者血清MMP-9、TIMP-1水平急性加重期表达水平高于与稳定期。MMP-9、TIMP-1预测肺血管重塑的效能分析,COPD患者急性加重期特异性与稳定期特异性比较,差异有统计学意义(P<0.01)。结论COPD患者血清MMP-9、TIMP-1的表达,可作为COPD病情评估和PVR预测的血清学生物参考标志物,具有重要的临床意义。

Objective To investigate the association of matrix metalloproteinase⁃9(MMP⁃9)with matrix metalloproteinase inhibitor(TIMP⁃1)expression in serum of patients with chronic obstructive pulmonary disease(COPD),and its predictive value for pulmonary vascular remodeling(PVR).Methods A total of 1,091 patients with COPD who were hospitalized from January 2019 to December 2021 were selected as research objects.Accord⁃ing to clinical diagnosis,the patients were divided into acute exacerbation group and stable stage group.Serum expression levels of MMP⁃9 and TIMP⁃1 in COPD patients were compared,and correlation analysis was conducted on statistical results.Moreover,the specificity of serum MMP⁃9 and TIMP⁃1 expression in The specificity of pulmo⁃nary vascular remodeling prediction was compared.Results The relative expression levels of MMP⁃9 and TIMP⁃1 in patients with acute exacerbation were significantly higher than those in stable COPD group(P<0.01).By Pearson correlation analysis,the expression of MMP⁃9 and TIMP⁃1 in serum of COPD patients showed a significant positive correlation.Serum levels of MMP⁃9 and TIMP⁃1 in patients with pulmonary vascular remodeling were higher in the acute exacerbation stage than in the stable stage group.Analysis of the efficacy of MMP⁃9 and TIMP⁃1 in predicting pulmonary vascular remodeling showed that the specificity of COPD patients at acute exacerbation stage was compared with that at stable stage(P<0.01),and the difference was statistically significant.Conclusion The expression of MMP⁃9 and TIMP⁃1 in serum of patients with chronic obstructive pulmonary disease can be used as serological biomarkers for COPD assessment and prediction of pulmonary vascular remodeling(PVR),which has important clinical significance.