超声内镜引导细针穿刺细胞学联合组织病理学对胰腺占位病变的诊断价值

Diagnostic values of endoscopic ultrasound⁃guided fine⁃needle aspiration cytology combined with histopa⁃thology for pancreatic space occupying lesions

目的探讨超声内镜引导下细针穿刺抽吸活检(endoscopic ultrasound-guided fine-needle aspiration,EUS-FNA)细胞学联合组织病理学对胰腺占位性病变的诊断价值。方法选取经EUS-FNA检查同时行细胞学和组织病理学检测的51例胰腺占位性病例资料,将细胞学、组织病理学及联合诊断结果与最终诊断结果进行比较,分析不同诊断方法的应用价值。结果细胞学诊断胰腺占位的敏感性、特异性和曲线下面积(AUC)分别为91.11%、100.00%和0.981;组织病理学对应的指标为75.56%、83.33%和0.852;两者联合检测的指标为95.56%、83.33%和0.987。两者联合诊断效能优于组织病理学(χ^(2)=4.55,P=0.03),差异有统计学意义。结论超声内镜引导细针穿刺细胞学联合组织病理学可提高胰腺占位病变的诊断率,且具有较高的安全性。

Objective To explore the diagnostic values of cytology combined with histopathology in the diagnosis of space occupying pancreatic lesions with endoscopic ultrasound⁃guided fine⁃needle aspiration(EUS⁃FNA).Methods The data of 51 patients with pancreatic space occupation were collected and all the patients underwent EUS⁃FNA and cytological and histopathological examination.The cytological,histopathological and com⁃bined diagnosis results were compared with the final diagnosis results,and the application values of different diag⁃nostic methods was analyzed.Results The sensitivity,specificity and area under curve(AUC)of the cytological examination were respectively 91.11%,100.00%and 0.981.The corresponding values for histopathological exami⁃nation were respectively 75.56%,83.33%and 0.852.The values of combined detection were respectively 95.56%,83.33%and 0.987.The diagnostic efficacy of the combination examination was better than that of histopathology(χ^(2)=4.55,P=0.03),and the difference was statistically significant.Conclusion Endoscopic ultrasound⁃guided fine needle aspiration cytology combined with histopathology can improve the diagnostic rate of pancreatic space occupying lesions and is considerably safe.