摘要
目的:归纳真实世界中喜炎平注射液治疗儿童上呼吸道感染患者的人群特征和用药特征。方法:基于2006年12月至2016年6月期间全国29家医院信息系统(HIS)数据仓库中至少使用过1次喜炎平注射液的小儿上呼吸道感染的患者信息,对纳入的24 062例患者的人群特征进行描述性分析;对医嘱中的合并用药信息选用数据挖掘中的Apriori算法建立模型,采用Clementine12.0来解析,并用复杂网络图使结果可视化。结果:患儿性别男13 730例(63.71%),女7 820例(36.29%),平均年龄(3.28±0.04)岁;真实世界中喜炎平注射液治疗儿童上呼吸道感染患者多用于一般病情;住院4~7 d的患者占比最高(57.65%);主要用于西医诊断为上呼吸道感染的患者,中医诊断主病为感冒,主要证型风热证、湿热证;喜炎平注射液主要与清热剂类中成药,维生素类,黏液溶解药,第2代头孢菌素合并使用。结论:真实世界中喜炎平注射液在治疗小儿上呼吸道感染的人群特征符合儿科呼吸系统感染性疾病人群的一般规律;合并用药特征分析反映了儿童上呼吸道感染患者症状的复杂多样性,为中西医结合治疗儿童上呼吸道感染的用药方案提供参考。
Objective:To summarize the population characteristics and medication characteristics of Xiyanping Injection in the treatment of children with upper respiratory tract infection(URTI)in the real world.Methods:Based on the medical data of children with URTI who had used Xiyanping Injection at least once in 29 Hospital Information System(HIS)data warehouses from December 2006 to June 2016,the population characteristics of 24062 patients were analyzed descriptively.The Apriori algorithm in data mining was used to build the model for the combined medication information in medical orders.Clementine12.0 was used to interpret the model,and the complex network graph was used to visualize the results.Results:There were 13730 males(63.71%)and 7820 females(36.29%),with an average age of(3.28±0.04)years.Xiyanping Injection in the real world was mostly used for the treatment of children with URTI in general pathogenic conditions.The proportion of patients with 4-7 d hospitalization was the highest(57.65%).Xiyanping Injection was mainly used for patients diagnosed with URTI by western medicine,and those diagnosed with cold of wind-heat syndrome and dampness-heat syndrome by traditional Chinese medicine(TCM).Xiyanping Injection was mainly used in combination with Chinese patent medicines such as heat-clearing agents,vitamins,mucilage-dissolving drugs,and the second-generation cephalosporin.Conclusion:In the real world,the population characteristics of Xiyanping Injection in the treatment of URTI in children conform to the general rule of the pediatric respiratory infectious disease population.The analysis of drug combination characteristics reflects the complex and diversity of symptoms in children with URTI,providing references for the drug regimen of integrated TCM and western medicine in the treatment of children with URTI.
作者
张家嘉
王志飞
谢雁鸣
李利寻
王淇
庄严
ZHANG Jiajia;WANG Zhifei;XIE Yanming;LI Lixun;WANG Qi;ZHUANG Yan(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;School of Statistics,Renmin University of China,Beijing 100872,China;Naval General Hospital of the People′s Liberation Army,Beijing 100853,China)
出处
《世界中医药》
CAS
2023年第5期662-667,共6页
World Chinese Medicine
基金
国家重点研发计划项目(2018YFC1707410)——中药上市后临床研究共性技术及方法技术体系研究。
关键词
喜炎平注射液
儿童上呼吸道感染
感冒
真实世界
医院信息系统
数据挖掘
中医药
联合用药
Xiyanping Injection
Upper respiratory tract infection in children
Cold
Real world
Hospital Information System(HIS)
Data mining
Traditional Chinese medicine
Drug combination