靶向药物所致口腔溃疡的中西医研究进展

Research Progress of Chinese and Western Medicine on Oral Ulcer Caused by Targeted Drugs

靶向药物已成为恶性肿瘤的主要治疗手段之一,随着其在临床上的广泛应用,相关的不良反应也逐渐显露。目前靶向药物所致口腔溃疡的发生率达20%以上,常致口腔疼痛、影响进食,导致营养不良,降低患者生活质量,甚则减量或停止治疗,影响预后。生活质量成为评价治疗效果和康复状况的重要指标已是共识,因此积极预防并规范治疗能给患者更大临床获益。复习口腔溃疡的病因病机,查阅近些年众医家的相关临床研究,分别从中医和西医两方面的认识和治疗进行综述,总结各治疗方法和临床疗效,为下一步临床医师开展靶向药物减毒增效研究提供参考。

Targeted drugs have become one of the main treatments for malignant tumors.With their wide application in clinic,related adverse reactions are gradually revealed.At present,the incidence of oral ulcers caused by targeted drugs is more than 20%,often causing oral pain,affecting eating,leading to malnutrition,reducing the quality of life of patients,and even reducing or stopping treatment,which affects the prognosis.It is a consensus that quality of life has become an important indicator for evaluating treatment effects and rehabilitation status,so active prevention and standardized treatment can bring greater clinical benefits to patients.Review the etiology and pathogenesis of oral ulcers,consult the relevant clinical research of many doctors in recent years,summarize the understanding and treatment of traditional Chinese medicine and western medicine,summarize the treatment methods and clinical efficacy,and develop targeted drugs for clinicians in the next step Toxic reduction and synergistic research provides reference.