文拉法辛与黛力新治疗功能性胃肠病伴焦虑障碍的成本-效果对比

Cost-effectiveness of Venlafaxine versus Delisine in the treatment of fun ctional gastrointestinal disorders with anxiety disorders

目的:分析比较文拉法辛与黛力新治疗功能性胃肠病(FGIDs)伴焦虑障碍的成本-效果。方法:选取2020年1月至2021年12月六盘水市第三人民医院收治的FGIDs伴焦虑障碍患者108例进行研究,随机分为文拉法辛组(n=54例)和黛力新组(n=54例)。两组在常规治疗的基础上分别给予文拉法辛与黛力新治疗。观察对比两组的临床疗效,分析两种药物的成本-效果。结果:文拉法辛组的治疗总有效率为90.74%,黛力新组的治疗总有效率为85.19%,二者相比差异无统计学意义(P>0.05)。治疗4周及8周后,两组的汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分均较治疗前降低,且文拉法辛组的HAMA评分、HAMD评分均低于黛力新组,差异有统计学意义(P<0.05)。文拉法辛与黛力新治疗FGIDs伴焦虑障碍的成本-效果相近。结论:针对FGIDs伴焦虑障碍患者,采用文拉法辛与黛力新治疗均能有效改善消化道症状,缓解焦虑、抑郁等负性情绪,且两药的成本-效果相近,但从长期疗效上看,文拉法辛更为突出。

Objective:To analyze and compare the cost-effectiveness of Venlafaxine and Delisine in the treatment of functional gastrointestinal disorders(FGIDs)associated with anxiety disorders.Methods:A total of 108 FGI Ds patients with anxiety disorder admitted to Liupanshui Third People’s Hospital from January 2020 to December 2021 were selected for this study,and randomly divided into Venlafaxine group(n=54 cases)and Delisin group(n=54 cases).The two groups were given Venlafaxine and Delisine respectively on the basis of conventional treatment.The clinical efficacy of the two groups was observed and compared,and the cost-effectiveness of the two drugs was analyzed.Results:The total effective rate of Venlafaxine group was 90.74%,and that of Delisin group was 85.19%,there was no statistical significance between them(P>0.05).After 4 and 8 weeks of treatment,Hamilton Anxiety Scale(HAMA)scores and Hamilton Depression Scale(HAMD)scores of the two groups were decreased compared with those before treatment,and Venlafaxine group’s HAMA scores and HAMD scores were lower than those of Delisin group,with statistical significance(P<0.05).Venlafaxine and Delisine showed similar cost-effectiveness in the treatment of FGIDs with anxiety disorders.Conclusions:For patients with FGIDs associated with anxiety disorder,both Effexor and Delisine can effectively improve gastrointestinal symptoms and relieve anxiety,depression and other negative emotions,and the cost-effectiveness of the two drugs is similar,but in terms of long-term efficacy,Effexor is more prominent.