布地格福治疗慢性阻塞性肺疾病对患者小气道功能和肺泡一氧化氮的影响

Effect of Budegfel on small airway function and alveolar nitric oxide in patients with chronic obstructive pulmonary disease

目的:探讨布地格福治疗慢性阻塞性肺疾病(COPD)对患者小气道功能和肺泡一氧化氮(CaNO)的影响。方法:选取2021年6月至2022年6月在山东省荣军总医院接受治疗的80例稳定期COPD患者作为研究对象。患者均给予布地格福吸入气雾剂吸入治疗30天。检测其治疗前后的肺功能和呼出气一氧化氮水平,观察肺泡一氧化氮水平(CaNO)、小气道功能(MEF25、MEF50、MEF75/25)的变化。结果:入组患者经布地格福吸入气雾剂治疗后小气道功能明显改善,MEF25、MEF50、MEF75/25明显增高,治疗前后的差异显著(P<0.01)。治疗后,患者的FeNO200、CaNO水平均显著下降,差异有显著性(P<0.01)。结论:布地格福吸入气雾剂能显著改善COPD患者的小气道功能,并明显降低其CaNO的水平。

Objective:To investigate the effects of Budegforo on small airway function and alveolar nitric oxide(CaNO)in patients with chronic obstructive pulmonary disease(COPD).Methods:A total of 80 patients with stable COPD who received treatment in Shandong Military General H ospital from June 2021 to J une 2022 were s elected as subjects.All patients were given Budegforo inhalation aerosol for 30 days.The changes of alveolar nitric oxide(CaNO)and small airway function(MEF25,MEF50,MEF75/25)were observed before and after treatment.Results:Small airway function was significantly improved after treatment with Budegforo inhalation aerosol,MEF25,MEF50 and MEF75/25 were significantly increased,and the difference before and after treatment was significant(P<0.01).After treatment,FeNO200 and CaNO levels were decreased significantly(P<0.01).Conclusions:Budegforo inhalation aerosol can significantly improve small airway function and reduce CaNO lev el in patients with COPD.