干扰素刺激基因与新型冠状病毒相互作用的研究进展

Research progress in the interaction between interferonstimulated genes and SARS-CoV-2

目前新型冠状病毒(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)感染所致的新型冠状病毒肺炎(corona virus disease,COVID-19)已成为威胁人类健康和安全的全球性流行性疾病。随着新突变株的不断出现,寻找有效治疗药物和靶点迫在眉睫。干扰素刺激基因(interferon-stimulated genes,ISGs)是由干扰素(interferons,IFNs)诱导后表达上调的一类基因,在宿主抵抗病毒感染过程中发挥着至关重要的作用。研究表明,ISGs能够靶向许多病毒复制的不同阶段发挥抗病毒作用,然而SARS-CoV-2也进化出各种策略干扰或逃避宿主天然免疫。因此,全面了解SARS-CoV-2与ISGs相互作用,对于设计抗病毒策略至关重要。本文简要综述不同ISGs抵抗SARS-CoV-2的作用机制,为开发新型的抗病毒药物提供思路和理论依据。

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has led to a global COVID-19 pandemic threatening human health and safety.However,it is urgent to find effective therapeutic agents and targets in response to the emergence of novel variants.Interferon-stimulated genes(ISGs),a class of genes upregulated by interferons(IFNs),play a crucial role in host resistance against viral infection.Studies have demonstrated that ISGs are able to target different stages of viral replication cycle to exert the effect against viral infection,whereas SARS-CoV-2 has evolved strategies to interfere with or evade host innate immune response.Comprehensively understanding the interactions between SARS-CoV-2 and ISGs is critical for the design of antiviral therapeutics.This review aims to briefly introduce the mechanisms of different ISGs against SARS-CoV-2,which provides ideas and theoretical basis for the development of novel antiviral agents.